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ACOMS+ 및 학술지 리포지터리 설명회

  • 한국과학기술정보연구원(KISTI) 서울분원 대회의실(별관 3층)
  • 2024년 07월 03일(수) 13:30
 

Journal of the Korean Association of Oral and Maxillofacial Surgeons

  • P-ISSN2234-7550
  • E-ISSN2234-5930
  • SCOPUS, KCI, ESCI

성인 골수 줄기세포의 조골세포로의 분화에서 유전자의 발현에 대한 연구

Exploring upregulated genes during osteogenic differentiation of hMSCs

Journal of the Korean Association of Oral and Maxillofacial Surgeons / Journal of the Korean Association of Oral and Maxillofacial Surgeons, (P)2234-7550; (E)2234-5930
2008, v.34 no.1, pp.11-18
안세경 (고려대학교)
임재석 (고려대학교)
권종진 (고려대학교)
이의석 (고려대학교)
장현석 (고려대학교)

Abstract

Human bone marrow mesenchymal stem cells are thought to be multipotent cells, which are present in adult marrow, that can replicate as undifferentiated cells and that have the potential to differentiate to lineages of mesenchymal tissues, including bone, cartilage, fat, tenden, muscle, and marrow stroma. Cells that have the characteristics of human mesenchymal stem cells could be isolated from marrow aspirates of human and animals. This study was designed to identify and characterize genes specifically expressed by osteogenic supplements -treated cells by suppression subtractive hybridization(SSH) method. The results were as follows: 1. 2 genes were upregulated genes in osteogenic diffeentiation of hMSCs, which is further proved by Northern blot analysis. 2. IGFBP-2 has been identified playing an important role in bone formation. 3. HF1 was also upregulated during osteogenic differentiation, but its role in bone formation is not clear yet

keywords
Bone marrow mesenchymal stem cells, Osteogenic supplements, Suppression subtractive hybridization(SSH), IGFBP-2, HF1, Bone marrow mesenchymal stem cells, Osteogenic supplements, Suppression subtractive hybridization(SSH), IGFBP-2, HF1

Journal of the Korean Association of Oral and Maxillofacial Surgeons