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ACOMS+ 및 학술지 리포지터리 설명회

  • 한국과학기술정보연구원(KISTI) 서울분원 대회의실(별관 3층)
  • 2024년 07월 03일(수) 13:30
 

Journal of the Korean Association of Oral and Maxillofacial Surgeons

  • P-ISSN2234-7550
  • E-ISSN2234-5930
  • SCOPUS, KCI, ESCI

The BMPs expression and histomorphometric study of β-TCP / rhBMP-2 Grafting on the rabbit cranial bone defects

Journal of the Korean Association of Oral and Maxillofacial Surgeons / Journal of the Korean Association of Oral and Maxillofacial Surgeons, (P)2234-7550; (E)2234-5930
2008, v.34 no.1, pp.49-58
임병섭 (한양대학교)
전재윤 (한양대학교)
박창주 (한양대학교)
임재정 (한양대학교)
황경균 (한양대학교)
심광섭 (한양대학교)

Abstract

The BMPs expression and histomorphometric study of β-TCP /rhBMP-2 Grafting on the rabbit cranial bone defects Byung-Sup Lim, Jae-Yoon Jeon, Chang-Joo Park, Jae-Jung Im, Kyung-Gyun Hwang, Kwang-Sup Shim Department of Dentistry/Oral and Maxillofacial Surgery, College of Medicine, Hanyang University, Korea * Corresponding author Kyung-Gyun Hwang, DDS, MSD, PhD. Dept. of Dentistry/OMFS, College of Medicine, Hanyang Univ. E-mail: hkg@hanyang.ac.kr Objective: The Purpose of the study was to investigate the bone morphogenic protein expression of rhBMP-2(recombinant human bone morphogenic protein-2) as singnaling molecule and β-TCP(Tricalcium phosphate) as a bone substitute and carrier medium of rhBMP-2. Materials and Methods: 16 rabbits divided into 2 group of each 8 rabbit. Two standardized bone defect, round bilateral defect was made in the cranium of the 8 rabbit of first group, and was grafted with 150~500μm diameter β-TCP 0.25g in one side, which was soaked with rhBMP-2, and autogenous bone was grafted on another side as a positive control. Second group of 8 rabbit, only β-TCP was grafted with same size and same manner. After 2, 4, 8, and 12 weeks, specimen was taken for microscopic immunohiostochemical and histomorphometric analysis. Result: Grafting β-TCP with rhBMP show the early formation of the bone regenerative factor (BMP-4) and more quantity of new bone formation than only use of β-TCP (8,12 week), even show less new bone formation than autogenous bone. Conclusion : The experimental study result that β-TCP graft combination with rhBMP-2 as a delivery system is an effective with osteoinductive capacity and biodegradable properties, so that provide clinical availibility of composite use in reconstruction of bony defect.

keywords
Beta-Tricalcium phosphate, bone graft, Bone Morphogenic Protein, bone substitute, histomorphometry, Immunohistochemistry

Journal of the Korean Association of Oral and Maxillofacial Surgeons