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ACOMS+ 및 학술지 리포지터리 설명회

  • 한국과학기술정보연구원(KISTI) 서울분원 대회의실(별관 3층)
  • 2024년 07월 03일(수) 13:30
 

Journal of the Korean Association of Oral and Maxillofacial Surgeons

  • P-ISSN2234-7550
  • E-ISSN2234-5930
  • SCOPUS, KCI, ESCI

Relationship between disease stage and renal function in bisphosphonate-related osteonecrosis of the jaw

Journal of the Korean Association of Oral and Maxillofacial Surgeons / Journal of the Korean Association of Oral and Maxillofacial Surgeons, (P)2234-7550; (E)2234-5930
2017, v.43 no.1, pp.16-22
김윤호 (부산대학교 치과대학)
박한결 (부산대학교)
최나래 (부산대학교)
김성원 (부산치대병원 구강악안면외과)
김규천 (부산대학교)
황대석 (부산대학교)
김용덕 (부산대학교)
신상훈 (부산대학교)
김욱규 (부산대학교)

Abstract

Objectives: Bisphosphonate is the primary cause of bisphosphonate-related osteonecrosis of the jaw (BRONJ). Bisphosphonates are eliminated from the human body by the kidneys. It is anticipated that bisphosphonate levels in the body will increase if the kidney is in a weak state or if there is sys-temic disease that affects kidney function. The aim of this study was to analyze the relevance of renal function in the severity of BRONJ.Materials and Methods: Ninety-three patients diagnosed with BRONJ in Pusan National University Dental Hospital from January 2012 to Decem-ber 2014 were included in this study. All patients underwent a clinical exam, radiographs, and serologic lab test, including urine analysis. The patient’s medical history was also taken, including the type of bisphosphonate drug, the duration of administration and drug holiday, route of administration, and other systemic diseases. In accordance with the guidelines of the 2009 position paper of American Association of Oral and Maxillofacial Surgeons, the BRONJ stage was divided into 4 groups, from stage 0 to 3, according to the severity of disease. IBM SPSS Statistics version 21.0 (IBM Co., USA) was used to perform regression analysis with a 0.05% significance level.Results: BRONJ stage and renal factor (estimated glomerular filtration rate) showed a moderate statistically significant correlation. In the group with higher BRONJ stage, the creatinine level was higher, but the increase was not statistically significant. Other factors showed no significant correlation with BRONJ stage. There was a high statistically significant correlation between BRONJ stage and ‘responder group’ and ‘non-responder group,’ but there was no significant difference with the ‘worsened group.’ In addition, the age of the patients was a relative factor with BRONJ stage.Conclusion: With older age and lower renal function, BRONJ is more severe, and there may be a decrease in patient response to treatment.

keywords
Osteomyelitis, Bisphosphonate-associated osteonecrosis of the jaw, Chronic renal diseases

Journal of the Korean Association of Oral and Maxillofacial Surgeons