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ACOMS+ 및 학술지 리포지터리 설명회

  • 한국과학기술정보연구원(KISTI) 서울분원 대회의실(별관 3층)
  • 2024년 07월 03일(수) 13:30
 

Journal of the Korean Association of Oral and Maxillofacial Surgeons

  • P-ISSN2234-7550
  • E-ISSN2234-5930
  • SCOPUS, KCI, ESCI

Gingival crevicular fluid levels of sclerostin in chronic periodontitis and healthy subjects

Journal of the Korean Association of Oral and Maxillofacial Surgeons / Journal of the Korean Association of Oral and Maxillofacial Surgeons, (P)2234-7550; (E)2234-5930
2018, v.44 no.6, pp.289-292
https://doi.org/10.5125/jkaoms.2018.44.6.289
Zeinab Rezaei Esfahrood (Shahid Beheshti University of Medical Sciences)
Zahra Yadegari (Shahid Beheshti University of Medical Sciences)
Setareh Kazemi Veysari (Shahid Beheshti University of Medical Sciences)
Mahdi Kadkhodazadeh (Shahid Beheshti University of Medical Sciences, Tehran, Iran)

Abstract

Objectives: Chronic periodontitis is a common inflammatory disease of the oral cavity that causes destruction of periodontal tissues and bone around the teeth. Sclerostin is a protein encoded by the SOST gene. In this study, gingival crevicular fluid (GCF) levels of sclerostin in patients with chronic periodontitis were compared with those of healthy subjects.Materials and Methods: In this case-control study, a total of 40 subjects were enrolled and divided into the healthy group (n=23) and chronic peri-odontitis group (n=17). GCF samples were collected, and the concentration of sclerostin was evaluated using enzyme-linked immunosorbent assay. Comparison of significance between groups was assessed using Mann-Whitney U test.Results: Sclerostin concentration was significantly higher in the chronic periodontitis group compared with the healthy group (P<0.005). Conclusion: Despite the limitations of this study, sclerostin can be a possible marker for assessment of periodontal health status.

keywords
Sclerostin, Periodontitis, Gingival crevicular fluid

Journal of the Korean Association of Oral and Maxillofacial Surgeons