Journal of the Korean Association of Oral and Maxillofacial Surgeons
- 권한신청
- P-ISSN2234-7550
- E-ISSN2234-5930
- SCOPUS, KCI, ESCI
ISSN : 2234-7550
Clinical-pathologic profile of head and neck rhabdomyosarcoma in children: a systematic review
Beatriz Della Terra Mouco Garrido (Bauru School of Dentistry, University of São Paulo, Bauru, Brazil)
Nelson Leonel Del Hierro Polanco (Bauru School of Dentistry, University of São Paulo, Bauru, Brazil)
Mattheus Augusto Siscotto Tobias (Bauru School of Dentistry, University of São Paulo, Bauru, Brazil)
Viviane da Silva Siqueira (Bauru School of Dentistry, University of São Paulo, Bauru, Brazil)
Cassia Maria Fischer Rubira (Bauru School of Dentistry, University of São Paulo, Bauru, Brazil)
Paulo Sérgio da Silva Santos (Bauru School of Dentistry, University of São Paulo, Bauru, Brazil)
Abstract
This systematic review aimed to analyze the clinicopathological profile and relevant prognostic factors of head and neck rhabdomyosarcoma in pediatric patients. The search was carried out in the electronic search portals PubMed, Lilacs, Embase, Scopus, and Web of Science. The search yielded studies that were then analyzed regarding study topic, data extraction, and risk of bias using the STROBE (Strengthening the Reporting of Observational Studies) guidelines. Finally, three studies were included for qualitative analysis. Most of the cases involved embryonic and alveolar rhabdomyosarcoma. Expression of MYOD1 was highly correlated with diagnosis of spindle cell/sclerosing rhabdomyosarcoma, which appears to have a poor prognosis in children. Furthermore, tumor size <5 cm and absence of metastasis accompanied by complete resection and administration of adjuvant therapies such as chemotherapy and radiotherapy favored a better prognosis.
- keywords
- MyoD1 myogenic differentiation protein, Rhabdomyosarcoma, Head and neck neoplasms, Spindle cell rhabdomyosarcoma
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