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open access
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ISSN : 0376-4672
The purpose of this study is to investigate the relationship between periodontal disease and coronavirus disease 2019 (COVID-19) as a respiratory disease, and to suggest its molecular biological mechanism. Oral bacteria and viruses can be aspirated into the respiratory tract and may cause respiratory diseases. The COVID-19 virus can inhabit, replicate and spread in the oral environment including dental plaque, saliva, and periodontal pockets. The COVID-19 virus can induce strong innate immunity and inflammatory responses by binding to the angiotensin-converting enzyme 2 receptors, which are abundantly present in the oral stratified epithelium in the oral cavity. The COVID-19 virus may activate inflammasome, one of inflammatory key factors in cell cytoplasm. In patients with periodontal disease, oral hygiene habits, professional oral cleaning, and plaque control management are effective for reducing the possibility of COVID-19 infection. This review is based on the evidences from COVID-19 related literature in the last two years.
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