open access
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open access
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ISSN : 0376-4672
Temporomandibular disorders (TMD) are challenging to treat despite various existing methods. Stress on the temporo mandibular joint (TMJ) leads to an accumulation of reactive oxygen species, promoting inflammation and cartilage degra dation. Resveratrol, a natural polyphenol, inhibits inflammatory pathways and suppresses chondrocyte apoptosis, making it a promising candidate for TMD treatment. This review analyzes six studies with 3 kinds of animals on the intra-articular application of resveratrol for treating arthritis. This paper aims to elucidate the potential of resveratrol administrations into the articular cartilage to improve severity of arthritis, providing a foundation for future research and clinical investigations.
1. Tanaka E, Detamore MS, Mercuri LG. Degenerative disorders of the temporomandibular joint: etiology, diagnosis, and treatment, J Dent Res 2008;87:296-307.
2. Scapino RP, Canham PB, Finlay HM, Mills DK. The behaviour of collagen fibres in stress relaxation and stress distribution in the jaw-joint disc of rabbits, Arch Oral Biol 1996;41:1039-1052.
3. Rastogi NK, Vakharia N, Hung OR. Perioperative anterior dislocation of the temporomandibular joint, Anesth Analg 1997;84:924-926.
4. Gil-Martinez A, Paris-Alemany A, Lopez-de-Uralde-Villanueva I, La Touche R. Management of pain in patients with temporomandibular disorder (TMD): challenges and solutions, J Pain Res 2018;11:571-587.
5. Wang X, Fan D, Cao X et al. The Role of Reactive Oxygen Species in the Rheumatoid Arthritis-Associated Synovial Microenvironment, Antioxidants (Basel) 2022;11.
6. Ahmad N, Ansari MY, Haqqi TM. Role of iNOS in osteoarthritis:Pathological and therapeutic aspects, J Cell Physiol 2020;235:6366-6376.
7. Lopes EBP, Filiberti A, Husain SA, Humphrey MB. Immune Contributions to Osteoarthritis, Curr Osteoporos Rep 2017;15:593-600.
8. Shaito A, Posadino AM, Younes N et al. Potential Adverse Effects of Resveratrol: A Literature Review, Int J Mol Sci 2020;21.
9. Shakibaei M, John T, Seifarth C, Mobasheri A. Resveratrol inhibits IL-1 beta-induced stimulation of caspase-3 and cleavage of PARP in human articular chondrocytes in vitro, Ann N Y Acad Sci 2007;1095:554-563.
10. Li W, Hu S, Chen X, Shi J. The Antioxidant Resveratrol Protects against Chondrocyte Apoptosis by Regulating the COX-2/NFkappaB Pathway in Created Temporomandibular Osteoarthritis, Biomed Res Int 2021;2021:9978651.
11. Yuce P, Hosgor H, Rencber SF, Yazir Y. Effects of Intra-Articular Resveratrol Injections on Cartilage Destruction and Synovial Inflammation in Experimental Temporomandibular Joint Osteoarthritis, J Oral Maxillofac Surg 2021;79:344 e341-344 e312.
12. Chen X, Lu J, An M et al. Anti-inflammatory effect of resveratrol on adjuvant arthritis rats with abnormal immunological function via the reduction of cyclooxygenase-2 and prostaglandin E2, Mol Med Rep 2014;9:2592-2598.
13. Ren H, Bao G, Muhamnad F et al. 2023.
14. Wang W, Sun L, Zhang P et al. An anti-inflammatory cell-free collagen/resveratrol scaffold for repairing osteochondral defects in rabbits, Acta Biomater 2014;10:4983-4995.
15. Wang J, Gao JS, Chen JW et al. Effect of resveratrol on cartilage protection and apoptosis inhibition in experimental osteoarthritis of rabbit, Rheumatol Int 2012;32:1541-1548.
16. Wang XD, Zhang JN, Gan YH, Zhou YH. Current understanding of pathogenesis and treatment of TMJ osteoarthritis, J Dent Res 2015;94:666-673.
17. Ouanounou A, Goldberg M, Haas DA. Pharmacotherapy in Temporomandibular Disorders: A Review, J Can Dent Assoc 2017;83:h7.
18. Wu M, Cai J, Yu Y et al. Therapeutic Agents for the Treatment of Temporomandibular Joint Disorders: Progress and Perspective, Front Pharmacol 2020;11:596099.
19. Moccia S, Nucci L, Spagnuolo C et al. Polyphenols as Potential Agents in the Management of Temporomandibular Disorders, Applied Sciences 2020;10.
20. Rana A, Samtiya M, Dhewa T et al. Health benefits of polyphenols:A concise review, J Food Biochem 2022;46:e14264.
21. de Sa Coutinho D, Pacheco MT, Frozza RL, Bernardi A. Anti-Inflammatory Effects of Resveratrol: Mechanistic Insights, Int J Mol Sci 2018;19.
22. Jhanji M, Rao CN, Sajish M. Towards resolving the enigma of the dichotomy of resveratrol: cis- and trans-resveratrol have opposite effects on TyrRS-regulated PARP1 activation, Geroscience 2021;43:1171-1200.
23. Orallo F. Comparative studies of the antioxidant effects of cisand trans-resveratrol, Curr Med Chem 2006;13:87-98.
24. Wenzel E, Somoza V. Metabolism and bioavailability of transresveratrol, Mol Nutr Food Res 2005;49:472-481.
25. Ornstrup MJ, Harslof T, Kjaer TN et al. Resveratrol increases bone mineral density and bone alkaline phosphatase in obese men: a randomized placebo-controlled trial, J Clin Endocrinol Metab 2014;99:4720-4729.
26. Taiwan Food and Drug Administration, 食品原料整合查詢平臺https://consumer.fda.gov.tw/Food/MaterialDetail. aspx?nodeID=160&id=17734, 2023.
27. Pasinetti GM, Wang J, Ho L et al. Roles of resveratrol and other grape-derived polyphenols in Alzheimer's disease prevention and treatment, Biochim Biophys Acta 2015;1852:1202-1208.
28. Hausenblas HA, Schoulda JA, Smoliga JM. Resveratrol treatment as an adjunct to pharmacological management in type 2diabetes mellitus--systematic review and meta-analysis, Mol Nutr Food Res 2015;59:147-159.
29. Adhami VM, Afaq F, Mukhtar H. Insulin-like growth factor-I axis as a pathway for cancer chemoprevention, Clin Cancer Res 2006;12:5611-5614.
30. Agarwal B, Campen MJ, Channell MM et al. Resveratrol for primary prevention of atherosclerosis: clinical trial evidence for improved gene expression in vascular endothelium, Int J Cardiol 2013;166:246-248.
31. Averilla JN, Oh J, Wu Z et al. Improved extraction of resveratrol and antioxidants from grape peel using heat and enzymatic treatments, J Sci Food Agric 2019;99:4043-4053.