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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

生津養血湯이 Streptozotocin으로 유발된 당뇨병 Rat 모델의 고혈당 및 간병증과 신병증에 미치는 영향

Hypoglycemic, Hepatoprotective, and Nephroprotective Effects of “Saengjinyanghyul-tang (Sh?ngj?ny?ngxu?-t?ng)” in Streptozotocin-Induced Diabetic SD Rats

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2006, v.27 no.2, pp.155-170
곽민아 (대구대학교 한방변원)
김민수 (동의대학교)
변준석 (대구한의대학교)
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Abstract

Objectives : This study was aimed to evaluate the hypoglycemic, hepatoprotective, and nephroprotective effects of “Saengjinyanghyul-tang (Shēngjīnyǎngxuè-tāng: SJYHT)” in streptozotocin (STZ)-induced diabetic SD rat model. Methods : SJYHT extracts were once a day dosed for 28 days at a dosage 1000, 500, and 250㎎/㎏/5㎖ from 25 days after STZ-dosing, and the changes on blood glucose levels, liver and kidney weight, serum AST, ALT, BUN and creatinine levels were observed with histological changes on the liver and kidney. Results : Increased blood glucose levels, and diabetic hepatopathy & nephropathy including increased serum AST, ALT, BUN and creatinine levels, histological changes after STZ-dosing were dose-dependently reduced by SJYHT extract-dosing. Conclusions : “SJYHT” water extracts have favorable hypoglycemic, hepatoprotective, and nephroprotective effects on the STZ-induced diabetic SD rats. Therefore, it is expected that “SJYHT” has potential for use in the management of diabetes and diabetic complications.

keywords
Saengjinyanghyul-tang (Shēngjīnyǎngxuè-tāng), diabetes, diabetic hepatopathy, diabetic nephropathy, Saengjinyanghyul-tang (Shēngjīnyǎngxuè-tāng), diabetes, diabetic hepatopathy, diabetic nephropathy


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