- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Effects of Pinelliae Rhizoma on the Obese Zucker Rats' Lipid of Blood Serum and Skeletal Muscles Fatty Acid Metabolism
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2006, v.27 no.2, pp.211-224
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(2006). Effects of Pinelliae Rhizoma on the Obese Zucker Rats' Lipid of Blood Serum and Skeletal Muscles Fatty Acid Metabolism. Journal of Korean Medicine, 27(2), 211-224.
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Abstract
Objectives:This study was performed to investigate the effects of Pinelliae rhizoma on blood serum lipids and skeletal muscle fatty acid metabolism of obese Zucke r rats. Methods and Materials: Experimental groups were divided into normal Zucker rats (lean control; non-treated), obese Zucker rats (fat control; non-treated) and Pinelliae rhizoma oral feeding obese Zucker rats (fat control; treated) for 6 separate experiments. Pinelliae rhizoma was investigated for effects on total body weight, serum gluco se content, total cholesterol and triglyceride content, free fatty acid con tent, PPARalpha, CS and beta-HAD. Results: 1. Triglyceride in blood serum showed a greater decrease in Pinellia rhizoma oral feeding group than the overweight control group. 2. PPARa showed a significant increase in Pinelliae rhizoma oral feeding group than overweight control group in skeletal muscle of SOL, EDL and as for protein FABPc, Pinelliae rhizoma oral feeding group saw a greater significant increase than the overweight control group in the skeletal muscle of SOL. 3. CS activity was seen greater increase for the Pinelliae rhizoma oral feeding group than the overweight control group in EDL Conclusions: As the experiment's results show, Pinelliae rhizoma effectively decreased the weight and triglyceride of the obese mouse, and somewhat affects the fat oxidation in the skeletal muscle.
- keywords
- Pinelliae rhizoma, fatty acid metabolism, obese zucker rats, PPARalpha, citrate synthase, beta-HAD., Pinelliae rhizoma, fatty acid metabolism, obese zucker rats, PPARalpha, citrate synthase, beta-HAD.
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