- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Hypoglycemic, Hepatoprotective, and Nephroprotective Effects of “Saengjinyanghyul-tang (Sh？ngj？ny？ngxu？-t？ng)” in Streptozotocin-Induced Diabetic SD Rats
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2006, v.27 no.2, pp.155-170
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(2006). Hypoglycemic, Hepatoprotective, and Nephroprotective Effects of “Saengjinyanghyul-tang (Sh？ngj？ny？ngxu？-t？ng)” in Streptozotocin-Induced Diabetic SD Rats. Journal of Korean Medicine, 27(2), 155-170.
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Abstract
Objectives : This study was aimed to evaluate the hypoglycemic, hepatoprotective, and nephroprotective effects of “Saengjinyanghyul-tang (Shēngjīnyǎngxuè-tāng: SJYHT)” in streptozotocin (STZ)-induced diabetic SD rat model. Methods : SJYHT extracts were once a day dosed for 28 days at a dosage 1000, 500, and 250㎎/㎏/5㎖ from 25 days after STZ-dosing, and the changes on blood glucose levels, liver and kidney weight, serum AST, ALT, BUN and creatinine levels were observed with histological changes on the liver and kidney. Results : Increased blood glucose levels, and diabetic hepatopathy & nephropathy including increased serum AST, ALT, BUN and creatinine levels, histological changes after STZ-dosing were dose-dependently reduced by SJYHT extract-dosing. Conclusions : “SJYHT” water extracts have favorable hypoglycemic, hepatoprotective, and nephroprotective effects on the STZ-induced diabetic SD rats. Therefore, it is expected that “SJYHT” has potential for use in the management of diabetes and diabetic complications.
- keywords
- Saengjinyanghyul-tang (Shēngjīnyǎngxuè-tāng), diabetes, diabetic hepatopathy, diabetic nephropathy, Saengjinyanghyul-tang (Shēngjīnyǎngxuè-tāng), diabetes, diabetic hepatopathy, diabetic nephropathy
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