- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Effects of Hwangryunhaedoktang on DSS-induced colitis
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2006, v.27 no.2, pp.182-195
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(2006). Effects of Hwangryunhaedoktang on DSS-induced colitis. Journal of Korean Medicine, 27(2), 182-195.
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Abstract
Effects of Hwangryunhaedoktang on DS-induced colitis Objectives: We examined the effect of Hwangryunhaedoktang (HH) on the experimental ulcerative colitis induced by dextran sulfate sodium (DSS). Methods: Experimental colitis was induced in rats by daily treatment wi th 5% DS in the drinking water for 5 days. Afterw ard, the rats were divided int o two groups: the control group was administered water and the sample group was administe red HH for 7 days. Results: The sample group provided HH for 7 days demonstrated fast reco very of body weight compared with the control group. Histologic change showe d fast regeneration of crypt and surface epithelial cells and decreased edema of the s ubmucosa and decreased lymphatic follicle of mucosa compared with the control group. I mmunohistochemical stain using COX-2 gene was decreased and there was localized Ki -67 positive reaction. Regeneration of surface epithelial cel and goblet cel in muco sa was observed by transmission electron microscope. Conclusion: These results indicate therapeutic effect of HH on DSS-induced colitis in rats.
- keywords
- Hwangryunhaedoktang, Colitis, dextran sulfate sodium, COX-2, Ki-67 protein, Hwangryunhaedoktang, Colitis, dextran sulfate sodium, COX-2, Ki-67 protein
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