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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

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露蜂房의 Peroxynitrite 제거 효과

Peroxynitrite Scavenging Activity of Vespae Nidus

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2006, v.27 no.2, pp.171-181
정지천 (동국대학교 한방병원)
신원용 (동국대학교)
정지천, & 신원용. (2006). 露蜂房의 Peroxynitrite 제거 효과. 대한한의학회지, 27(2), 171-181.
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Abstract

Objectives : Peroxynitrite (ONOO-), superoxide anion (․O2-) and nitric oxide (NO) is a cytotoxic species that can oxidize several cellular components such as proteins, lipids and DNA. It has been implicated in the aging process and age-related disease such as Alzheimer's disease, rheumatoid arthritis, cancer and atherosclerosis. The aim of this study was to investigate scavenging activities for ONOO- and its precursors, NO and ․O2- of Vespae Nidus. Methods : Dichlorodihydrofluorescein diacetate (DCFDA), 4,5-diaminofluorescein (DAF-2) and dihydrorhodamine 123 (DHR 123) were used to investigate scavenging activities of ONOO-, NO, ․O2-. six months old ICR mice were used. After mice were injected with Lipopolysaccharides (LPS), the organizations of kidney were evaluated. And three comparison groups of ICR mice were used : normal group, experimetal group that was feed Vespae Nidus extract and then injected with LPS, control group that was injected with LPS. Scavenging activities of ONOO-, NO, ․O2- in these groups were measured in the same way. Results : Vespae Nidus markedly scavenged authentic ONOO-, ․O2- and NO. It also inhibited ONOO- induced by ․O2- and NO which are derived from SIN-1. Furthermore, it inhibited ONOO-, ․O2-, NO generation by Vespae Nidus in LPS-treated ICR mouse kidney postmitochondria. Conclusions : These results suggest that Vespae Nidus might be developed as an effective ONOO-, ․O2-, NO scavenger for the prevention of aging process and age-related diseases.

keywords
Vespae Nidus, peroxynitrite, nitric oxide, reactive oxygen species


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