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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

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황련해독탕이 DSS로 유발된 흰쥐의 궤양성 대장염에 미치는 영향

Effects of Hwangryunhaedoktang on DSS-induced colitis

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2006, v.27 no.2, pp.182-195
안중환 (동국대학교 한방병원)
최은영 (동국대학교 한의과대학)
이성환 (동국대학교 한의과대학)
박인식 (동국대학교)
임성우 (동국대학교)
안중환, 최은영, 이성환, 박인식, & 임성우. (2006). 황련해독탕이 DSS로 유발된 흰쥐의 궤양성 대장염에 미치는 영향. 대한한의학회지, 27(2), 182-195.
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Abstract

Effects of Hwangryunhaedoktang on DS-induced colitis Objectives: We examined the effect of Hwangryunhaedoktang (HH) on the experimental ulcerative colitis induced by dextran sulfate sodium (DSS). Methods: Experimental colitis was induced in rats by daily treatment wi th 5% DS in the drinking water for 5 days. Afterw ard, the rats were divided int o two groups: the control group was administered water and the sample group was administe red HH for 7 days. Results: The sample group provided HH for 7 days demonstrated fast reco very of body weight compared with the control group. Histologic change showe d fast regeneration of crypt and surface epithelial cells and decreased edema of the s ubmucosa and decreased lymphatic follicle of mucosa compared with the control group. I mmunohistochemical stain using COX-2 gene was decreased and there was localized Ki -67 positive reaction. Regeneration of surface epithelial cel and goblet cel in muco sa was observed by transmission electron microscope. Conclusion: These results indicate therapeutic effect of HH on DSS-induced colitis in rats.

keywords
Hwangryunhaedoktang, Colitis, dextran sulfate sodium, COX-2, Ki-67 protein, Hwangryunhaedoktang, Colitis, dextran sulfate sodium, COX-2, Ki-67 protein


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