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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

A Reciew on Herbal Medicinal Products Associated with Toxic Events in Korea

Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2007, v.28 no.1, pp.1-10




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Abstract

Background: There has been renewed interest in complementary alternative medicine around the world for a decade. On the other hand, the issue of safety of herbal medicine in Korea has been continuously questioned. Issues raised have included not only chemical residue or heavy metals caused by pollution, but also the toxicity of herbal medicine itself. Objectives: The purpose of this study was to review some herbal medicines subject to controversy of toxicity and figure out what kind of problems they evidence. Methods: In this review, PubMed was used to search medical journals. Keywords such as ‘herb, or herbal medicine’, ‘safety, or adverse events, or adverse effect, or toxicity, or liver injury’ were applied. Journals were selected by four inclusion criteria, as objectives should be human, researchers should be medical doctors, literature written in the English language, and types of journals should be meta-analysis or practice guideline or reviews. Finally, 9 cases from 60 journals were included in this review. Results: We reviewed 13 herbal medicines for controversy of toxicity such as ephedra (Mahuang), Aristolochia fangchi, Aristolochia manshuriensis, licorice, skullcap, germander, Syo-saiko-to (Xiao-chai-hu-tang), Chelidonium majus, mistletoe, Dictamnus dasycarpus and madder. Conclusions: It suggested that 'who it is prescribed for' is one of the most important factors to identify the causes of toxicity in herbal medicine and dietary supplements, under specific conditions in Korea.

keywords
herb, toxicity, adverse events, ephedra, Aristolochia, licorice


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