- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Effects of Jiyutang on DSS-induced Colitis of the Mouse
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2007, v.28 no.1, pp.187-197
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(2007). Effects of Jiyutang on DSS-induced Colitis of the Mouse. Journal of Korean Medicine, 28(1), 187-197.
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Abstract
Objectives:We examined the effect of Jiyutang(JYT) on the experimental ulcerative colitis induced by dextran sulfate sodium(DSS). Methods:Experimental colitis was induced in mice by daily treatment with 3% DSS in the drinking water for 5 days. Afterward, the mice were divided into two groups: the control group was administered water and the sample group was administered JYT for 7 days. Results:The sample group provided JYT for 7 days demonstrated faster recovery of body weight compared with the control group. Histologic change showed faster regeneration of crypt and surface epithelial cells, decreased edema of the submucosa, and decreased lymphatic follicles of mucosa compared with the control group. Immunohistoche- mical stain using COX-2 gene was decreased. Regeneration of surface epithelial cells and goblet cells in mucosa was observed by transmission electron microscope. Conclusion:These results indicate therapeutic effect of JYT on DSS-induced colitis in mice. Keywords:Jiyutang, colitis, dextran sulfate sodium, COX-2, HSP.
- keywords
- Jiyutang, colitis, dextran sulfate sodium, COX-2, HSP
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