- P-ISSN 1010-0695
- E-ISSN 2288-3339
- Log In/Sign Up
- P-ISSN1010-0695
- E-ISSN2288-3339
Article Detail
Home > Article Detail
Association between Genetic Polymorphisms of the CYP2C19,CYP2D6 and Types of Sasang Constitutional Medicine
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2007, v.28 no.1, pp.51-62
&
(2007). Association between Genetic Polymorphisms of the CYP2C19,CYP2D6 and Types of Sasang Constitutional Medicine. Journal of Korean Medicine, 28(1), 51-62.
- Downloaded
- Viewed
Abstract
Objectives: The types of Sasang constitutional medicine (SCM) have definite effect on response to herbal drugs. The majority of human P450 dependent xenobiotic metabolism is carried out by polymorphic enzymes which can cause abolished, altered or enhanced metabolism. Therefore, we evaluated the relation of major CYP2C19, 2D6 polymorphism with Sasang types. Methods: 214 healthy subjects were recruited with informed consent; 172 among them had Sasang diagnosis by QSCC2. CYP2D6, 2C19 polymorphism were determined by PCR-RFLP method. Results: None of the Sasang types showed significant difference in CYP2D6, 2C19 polymorphism. However, the Tae-um type showed relatively low frequency of CYP2D6 *10/*10 polymorphisms with low activity (p=0.110). In the So-yang type, specific *3/*3 genotype which is a poor metabolizer of CYP2C19*3 was detected (p=0.078). Conclusion: These results suggest that the Tae-um type which is said to have high liver function in SCM has the tendency of high drug-metabolizing enzyme activity. With further study, the CYP polymorphism could serve as a scientific tool for SCM diagnosis.
- keywords
- Sasang constitutional medicine, Sasang diagnosis, polymorphism, cytochrome P450., Sasang constitutional medicine, Sasang diagnosis, polymorphism, cytochrome P450.
- Downloaded
- Viewed
- 0KCI Citations
- 0WOS Citations
Other articles from this issue
- A Reciew on Herbal Medicinal Products Associated with Toxic Events in Korea
- Effectiveness of Bee Venom Acupuncture on Shoulder Pain after stroke
- A Comparative study on Distinction of Patients with Stroke in the Case of the First Attack and Recurrence
- Analysis of 363 Consecutive Patients with Acute Ischemic Stroke from the Hanbang Stroke Registry
- Midterm Assessment on Forecasting Study of Korean Traditional Medicine
- Association between Genetic Polymorphisms of the CYP2C19,CYP2D6 and Types of Sasang Constitutional Medicine
- Effects of Mahuang for Weight Loss in Healthy Adults: A Double-Blind, Controlled, Randomized, Clinical Trial
- Economic Evaluation of Eastern, Western and Collaborative Treatment for Patients with Frozen Soulder Pain
- Comparison of Therapeutic Effects on Carpal Tunnel Syndrome between Oriental and Western Medicine
- Review on Teaching Traditional Korean Medical Students with English Medical Journals
- Effect of Mahuang on Heart Rate Variability in Adults: a Double-Blind, Placebo-Controlled, Randomized Trial
- Assessment on Forecasting Study of Traditional Chinese Medicine(1990-2010)
- Differences Between Facial Skin Temperature of the Paralyzed Side and Those of the Normal Side in Bell's Palsy Patients
- Studies on the Antioxidant Effects of Carthami Flos Extract
- Studies on the Antioxidant Effects of Mori Folium Extract
- A Study on VDT Syndrome by Sasang Constitution of High School in Su-won City
- A Study on Recognition by Korean Medicine Practitioners of Postpartum Disease and Treatments
- Effects of Jiyutang on DSS-induced Colitis of the Mouse
- Protective Effect of Red Ginseng and Paeonia radix against Nitric Oxide-Induced Apoptosis in Human Neuroblastoma SK-N-MC cells
- Effects of Rhizoma Arisaematis on Lipid and Glucose Metabolism and Hisstochemical Changes of Rats Fed High Fat Diet
- A Preliminary Study on the Inhibitory Effect of Chunghyul-dan on Stroke Recurrence in Patients with Small Vessel Disease
- Effects of Iksujisundan on Renal function, Peroxynitrite Scavenging Activity and Polyol in Streptozotocin-induced Diabetic Rats
- A Study on the Relationship among Hair Tissue Mineral Analysis Autonomic Functions and Obesity
- more
Recommanded Articles
This website recommended the use the Chrome browser for journal website.