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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

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마황복용이 정상인의 심박변이도에 미치는 영향에 대한 무작위배정 이중맹검 임상연구

Effect of Mahuang on Heart Rate Variability in Adults: a Double-Blind, Placebo-Controlled, Randomized Trial

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2007, v.28 no.1, pp.105-116
손동혁 (우석대학교 한의과대학)
형례창 (우석대학교 한의과대학)
김락형 (우석대학교 한의과대학)
정승일 (재단법인전주생물소재연구소)
서의석 (우석대학교 한의과대학)
장인수 (우석대학교 한의과대학)
손동혁, 형례창, 김락형, 정승일, 서의석, & 장인수. (2007). 마황복용이 정상인의 심박변이도에 미치는 영향에 대한 무작위배정 이중맹검 임상연구. 대한한의학회지, 28(1), 105-116.
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Abstract

Objectives: Mahuang (Ephedra sinica), well known as an herbal medicine in the East and West, contains a relatively high percentage of ephedrine known as sympathomimetic alkaloid. We investigated the effects of Mahuang on sympathetic nervous system with heart rate variety (HRV). Time and frequency domain analysis of HRV is a noninvasive technique capable of providing information on autonomic modulation of the sinus node. Methods: We investigated 57 healthy volunteers consisting of 37 subjects in the Mahuang group and 20 subjects in the placebo group. Study form was a randomized, placebo-controlled, double-blind clinical trial. The 37 subjects in the Mahuang group took 3 Mahuang capsules (1 capsule equivalent to 2g herb Mahuang) twice a day at 10 a.m. and 2 p.m., while the 20 subjects in the placebo group took 3 placebo-capsules filled with glutinous rice powder at the same times. Mahuang medicine and placebo medicine were made into opaque capsules. We measured HRV at 3 p.m. 1 or 2 days before medication and at 3 p.m. after medication. Results: Mean-RR and SDNN of the Mahuang group significantly decreased compared with that of the placebo group, but the heart rate of the Mahuang group significantly increased compared with the placebo. HRV-Index, RMSSD and SDSD of the Mahuang group significantly decreased compared with that of the placebo group, but PNN50 of the Mahuang group significantly increased compared with placebo. Ln(TP), Ln(VLF), Ln(LF) and Ln(HF) of the Mahuang group significantly decreased compared with those of the placebo group. There were no significant differences in normalized LF, normalized HF and LF/HF ratio between the Mahuang and placebo groups. Conclusion: The results suggest that Mahuang in healthy adults tends to reduce the autonomic nervous system within the normal range.

keywords
Ephedra, Mahuang, heart rate variability (HRV), clinical trial, herbal medicine, Ephedra, Mahuang, heart rate variability (HRV), clinical trial, herbal medicine


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