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상엽 추출물의 항산화효과에 대한 연구

Studies on the Antioxidant Effects of Mori Folium Extract

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2007, v.28 no.1, pp.148-158
이지은 (경원대학교 한의과대학)
송윤경 (경원대학교 한의과대학)
임형호 (경원대학교 한의과대학)
이지은, 송윤경, & 임형호. (2007). 상엽 추출물의 항산화효과에 대한 연구. 대한한의학회지, 28(1), 148-158.
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Abstract

Objective : The objective of this study was to investigate the antioxidant effects of Mori Folium extract. Methods : Total antioxidant status was examined by total antioxidant capacity(TAC) and total antioxidant response (TAR) against potent free radical reactions. The effect of Mori Folium extract was examined by measuring total phenolic content, concentration at which 1,1-diphenyl-2-picrylhydrazyl(DPPH) radical scavenging activity was inhibited, inhibitory effect on lipid peroxidation, and the effect on reactive oxygen species(ROS) generation. Results : 1. TAC and TAR of Mori Folium extract at the concentration of 5 / were 1.61 and 1.24 mM Trolox equivalents, respectively. 2. Total phenolic content of Mori Folium extract at the concentration of 5 / was 1.70 mM gallic acid equivalent. 3. Concentration of Mori Folium extract at which DPPH radical scavenging activity was inhibited by 50% was 2.29 / as compared to 100% by pyrogallol solution as a reference. 4. The inhibitory effect of the extract on lipid peroxidation was examined using rat liver mitochondria induced by FeSO4/ascorbic acid. Mori Folium extract at the concentration of 10 / significantly decreased thiobarbituric acid reactive substances(TBARS) concentration. The extract prevented lipid peroxidation in a dose-dependent manner. 5. The effect of Mori Folium extract on reactive oxygen species(ROS) generation was examined using a cell-free system induced by hydrogen peroxide/FeSO4. Addition of 1 / of Mori Folium extract significantly reduced dichlorofluorescein(DCF) fluorescence. The extract caused concentration-dependent attenuation of the increase in DCF fluorescence, indicating that the extract significantly prevented ROS generation in vitro. Conclusion : The antioxidant effects of Mori Folium extract seem to be due, at least in part, to the prevention of free radical-induced oxidation, followed by inhibition of lipid peroxidation.

keywords
Mori Folium, antioxidant, free radical, lipid peroxidation, reactive oxygen species, Mori Folium, antioxidant, free radical, lipid peroxidation, reactive oxygen species


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