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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

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Dextran Sulfate Sodium으로 유발된 생쥐의 대장염에 미치는 지유탕의 효과

Effects of Jiyutang on DSS-induced Colitis of the Mouse

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2007, v.28 no.1, pp.187-197
이성환 (동국대학교 한의과대학)
최흥민 (동국대학교 한의과대학)
임성우 (동국대학교 한의과대학)
이성환, 최흥민, & 임성우. (2007). Dextran Sulfate Sodium으로 유발된 생쥐의 대장염에 미치는 지유탕의 효과. 대한한의학회지, 28(1), 187-197.
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Abstract

Objectives:We examined the effect of Jiyutang(JYT) on the experimental ulcerative colitis induced by dextran sulfate sodium(DSS). Methods:Experimental colitis was induced in mice by daily treatment with 3% DSS in the drinking water for 5 days. Afterward, the mice were divided into two groups: the control group was administered water and the sample group was administered JYT for 7 days. Results:The sample group provided JYT for 7 days demonstrated faster recovery of body weight compared with the control group. Histologic change showed faster regeneration of crypt and surface epithelial cells, decreased edema of the submucosa, and decreased lymphatic follicles of mucosa compared with the control group. Immunohistoche- mical stain using COX-2 gene was decreased. Regeneration of surface epithelial cells and goblet cells in mucosa was observed by transmission electron microscope. Conclusion:These results indicate therapeutic effect of JYT on DSS-induced colitis in mice. Keywords:Jiyutang, colitis, dextran sulfate sodium, COX-2, HSP.

keywords
Jiyutang, colitis, dextran sulfate sodium, COX-2, HSP


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