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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

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A Preliminary Study on the Inhibitory Effect of Chunghyul-dan on Stroke Recurrence in Patients with Small Vessel Disease

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2007, v.28 no.1, pp.224-236
조기호 (경희대학교)
지남규 (경희대학교)
정우상 (경희대학교)
박성욱 (경희대학교)
Sang-kwan Moon (Kyung-Hee University)
고창남 (경희대학교)
Young-suk Kim (Kyung-Hee University)
Hyung-sup Bae
조기호, 지남규, 정우상, 박성욱, Sang-kwan, M. , 고창남, Young-suk, K. , & Hyung-sup, B. (2007). . 대한한의학회지, 28(1), 224-236.
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Abstract

Background: Chunghyul-dan is a combinatorial herbal medicine; previous studies reported it had therapeutic effects for microangiopathy, a major part in the progression of small vessel disease, as well as having anti-hypertensive, anti-hyperlipidemic, anti-apoptotic, anti-oxidative, and anti-inflammatory activities. Therefore, we examined the inhibitory effect of Chunghyul-dan on stroke recurrence in patients with small vessel disease. Methods: We prescribed Chunghyul-dan at 600 mg a day to patients with small vessel disease, and monitored stroke recurrence, drug compliances, and adverse effect for 1 year. We then performed follow-up brain MRI to find new vascular lesions after 1 year of Chunghyul-dan medication. For the subjects lost to follow-up, we assessed their prognosis after 1 year by telephone. Results: There were 73 subjects treated with Chunghyul-dan for 1 year; new vascular events were found in 3. Of the 85 subjects lost to follow-up, fifty four could be contacted, and eight of them had stroke recurrence. One year of Chunghyul-dan medication reduced the odds ratio of stroke recurrence by 75% compared to the subjects lost to follow-up and the rate increased to 88%, when adjusted for other relevant risk factors for stroke occurrence. These reductions were much higher than those of aspirin and other kinds of conventional anti-platelets. There was no adverse effect in any of the study subjects. Conclusions: We suggest Chunghyul-dan could be useful for inhibition of stroke recurrence. Further study with a randomized controlled trial is needed to confirm this suggestion.

keywords
Stroke recurence, smal vesel Stroke recurrence, small vessel disease, Chunghyul-dan


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