- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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The Effects of Gagbyungyunsoo-tanghap Zeungsonbakchul-san(GYZB) Hot Water Extract & Ultra-fine Powder on the Alzheimer's Disease Model
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2007, v.28 no.2, pp.137-154
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(2007). The Effects of Gagbyungyunsoo-tanghap Zeungsonbakchul-san(GYZB) Hot Water Extract & Ultra-fine Powder on the Alzheimer's Disease Model. Journal of Korean Medicine, 28(2), 137-154.
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Abstract
Objective : This experiment was designed to investigate the effect of the GYZB hot water extract & ultra-fine powder on the Alzheimer's disease model induced by amyloid β protein (βA). Method : We measured the effects of the GYZB hot water extract on expression of IL-1β, IL-6 mRNA and production of IL-6, TNF-α in the BV2 microglial cell line treated with lipopolysaccharide (LPS). The effects of the GYZB hot water extract & ultra-fine powder on (1) the behavior, (2) expression of IL-1β and TNF-α, (3) glucose in serum, (4) the infarction area of the hippocampus, and brain tissue injury in mice induced with Alzheimer's diseased by βA were investigated. Results : The GYZB hot water extract suppressed the expression of IL-1β and IL-6 mRNA and significantly suppressed the production of IL-6 and TNF-α in the BV2 microglial cell line treated with LPS. The GYZB hot water extract & ultra-fine powder showed a significant inhibitory effect on the memory deficit of the mice with Alzheimer's disease induced by βA in the Morris water maze experiment, which measured stop-through latency and distance movement-through latency. The GYZB ultra-fine powder significantly suppressed the expression of IL-1β and TNF-α protein, and the GYZB hot water extract significantly suppressed the expression of TNF-α protein in the microglial cell of mice with Alzheimer's disease induced by βA. The GYZB hot water extract & ultra-fine powder reduced the infarction area of hippocampus in the mice with Alzheimer's disease induced by βA. Conclusions : These results suggest that GYZB hot water extract & ultra-fine powder may be effective for the prevention and treatment of Alzheimer's disease. Investigation into the clinical use of GYZB for Alzheimer's disease is suggested for future research.
- keywords
- Alzheimer's disease, Gagbungyunsoo-tanghap Zeungsonbakchul-san (GYZB), hot water extract, ultra-fine powder, Alzheimer's disease, Gagbungyunsoo-tanghap Zeungsonbakchul-san (GYZB), hot water extract, ultra-fine powder
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