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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

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각병연수탕합증손백출산 열수추출물, 초미세분말제형이Alzheimer's Disease 병태 모델에 미치는 영향

The Effects of Gagbyungyunsoo-tanghap Zeungsonbakchul-san(GYZB) Hot Water Extract & Ultra-fine Powder on the Alzheimer's Disease Model

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2007, v.28 no.2, pp.137-154
최보윤 (대전대학교 한의과대학)
정인철 (대전대학교 한의과대학)
이상룡 (대전대학교 한의과대학)
최보윤, 정인철, & 이상룡. (2007). 각병연수탕합증손백출산 열수추출물, 초미세분말제형이Alzheimer's Disease 병태 모델에 미치는 영향. 대한한의학회지, 28(2), 137-154.
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Abstract

Objective : This experiment was designed to investigate the effect of the GYZB hot water extract & ultra-fine powder on the Alzheimer's disease model induced by amyloid β protein (βA). Method : We measured the effects of the GYZB hot water extract on expression of IL-1β, IL-6 mRNA and production of IL-6, TNF-α in the BV2 microglial cell line treated with lipopolysaccharide (LPS). The effects of the GYZB hot water extract & ultra-fine powder on (1) the behavior, (2) expression of IL-1β and TNF-α, (3) glucose in serum, (4) the infarction area of the hippocampus, and brain tissue injury in mice induced with Alzheimer's diseased by βA were investigated. Results : The GYZB hot water extract suppressed the expression of IL-1β and IL-6 mRNA and significantly suppressed the production of IL-6 and TNF-α in the BV2 microglial cell line treated with LPS. The GYZB hot water extract & ultra-fine powder showed a significant inhibitory effect on the memory deficit of the mice with Alzheimer's disease induced by βA in the Morris water maze experiment, which measured stop-through latency and distance movement-through latency. The GYZB ultra-fine powder significantly suppressed the expression of IL-1β and TNF-α protein, and the GYZB hot water extract significantly suppressed the expression of TNF-α protein in the microglial cell of mice with Alzheimer's disease induced by βA. The GYZB hot water extract & ultra-fine powder reduced the infarction area of hippocampus in the mice with Alzheimer's disease induced by βA. Conclusions : These results suggest that GYZB hot water extract & ultra-fine powder may be effective for the prevention and treatment of Alzheimer's disease. Investigation into the clinical use of GYZB for Alzheimer's disease is suggested for future research.

keywords
Alzheimer's disease, Gagbungyunsoo-tanghap Zeungsonbakchul-san (GYZB), hot water extract, ultra-fine powder, Alzheimer's disease, Gagbungyunsoo-tanghap Zeungsonbakchul-san (GYZB), hot water extract, ultra-fine powder


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