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  • 한국과학기술정보연구원(KISTI) 서울분원 대회의실(별관 3층)
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  • P-ISSN2233-4203
  • E-ISSN2093-8950
  • ESCI, SCOPUS, KCI

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  • P-ISSN 2233-4203
  • E-ISSN 2093-8950

Identfication of Phase I and Phase II Metabolites of Hesperetin in Rat Liver Microsomes by Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry

Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2011, v.2 no.1, pp.20-23
https://doi.org/10.5478/MSL.2011.2.1.020
Unyong Kim (Chung-Ang university, Korea institute of Science and Technology)
Sang Beom Han (Chung-Ang university)
Oh-Seung Kwon (Korea Institute of Science and Technology)
Hye Hyun Yoo (Hanyang University)
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Abstract

The purpose of this study is to investigate the in vitro metabolism of hesperetin, a bioflavonoid. Hesperetin was incubatedwith rat liver microsomes in the presence of NADPH and UDP-glucuronic acid for 30 min. The reaction mixture was analyzedby liquid chromatography-ion trap mass spectrometer and the chemical structures of hesperetin metabolites were characterzed basedon their MS/MS spectra. As a result, a total of five metabolites were detected in rat liver microsomes. The metabolites were identifiedas a demethylated metabolite (eriodictyol), two hesperetin glucuronides, and two eriodictyol glucuronides.

keywords
Hesperetin, in vitro Metabolism, Rat Liver Microsomes, LC/MS


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투고일Submission Date
2011-02-23
수정일Revised Date
2011-03-12
게재확정일Accepted Date
2011-03-12
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