바로가기메뉴

본문 바로가기 주메뉴 바로가기

ACOMS+ 및 학술지 리포지터리 설명회

  • 한국과학기술정보연구원(KISTI) 서울분원 대회의실(별관 3층)
  • 2024년 07월 03일(수) 13:30
사전등록 바로가기
 

logo

메뉴
search

ISSN : 0376-4672

논문 상세

이전 다음
논문 투고

61권 7호

제2형 당뇨모델 생쥐에서 치주인대조직 내 항상성조절인자 변화: 예비연구

Altered homeostatic factor of db/db mice’s periodontal ligament: A pilot study

최원준 (서울대학교 치의학전문대학원 치과교정학교실)
Ni Xiong (서울대학교 치의학전문대학원 치과교정학교실)
임원희 (서울대학교 치의학전문대학원 치과교정학교실)
대한치과의사협회지 / The Journal of the Korean Dental Association, (P)0376-4672; (E)2713-7961
2023, v.61 no.7, pp.460-468
https://doi.org/10.22974/jkda.2023.61.7.002
최원준, Ni, X. , & 임원희. (2023). 제2형 당뇨모델 생쥐에서 치주인대조직 내 항상성조절인자 변화: 예비연구. 대한치과의사협회지, 61(7), 460-468, https://doi.org/10.22974/jkda.2023.61.7.002

Abstract

Purpose: Diabetes is a risk factor for periodontal disease and can cause alveolar bone loss. The purpose of this study was to explore the effect of diabetes on homeostatic factor of periodontal tissue using leptin receptor (db/db) mice. Materials and Methods: The db/db mice(experimental group) were compared with the wild type mice (control group) using histology and immunohistochemical analyses. Collagen fibers were evaluated using H&E, picrosirius red, fibromodu lin staining and osteogenic factors (periostin, osteopontin, osteocalcin, osterix), and factors related to osteoclasts (OPG, RANKL) in the PDL were investigated. Results: Collagen fibers and osteogenic factors in the PDL showed no differences between a control and an experimental group. In an experimental group, expression of receptor activator of nuclear factor kappa-Β ligand (RANKL) was similar compared with a control group, while expression of osteoprotegerin (OPG) was decreased. Conclusions: RANKL/OPG ratio may be one of homeostatic factors related to bone remodeling in diabetic mice.

keywords
diabetes, homeostasis, periodontal tissue, RANKL, OPG

참고문헌

1.

1. Lin KY, Hsih WH, Lin YB, Wen CY, Chang TJ. Update in the epidemiology, risk factors, screening, and treatment of diabetic retinopathy. J Diabetes Investig 2021;12:1322-1325.

2.

2. Cho NH, Shaw JE, Karuranga S, et al. IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract 2018;138:271-281.

3.

3. Mealey BL, Ocampo GL. Diabetes mellitus and periodontal disease. Periodontol 2000 2007;44:127-153.

4.

4. Mealey BL, Moritz AJ. Hormonal influences: effects of diabetes mellitus and endogenous female sex steroid hormones on the periodontium. Periodontol 2000 2003;32:59-81.

5.

5. Cianciola LJ, Park BH, Bruck E, Mosovich L, Genco RJ. Prevalence of periodontal disease in insulin-dependent diabetes mellitus (juvenile diabetes). J Am Dent Assoc 1982;104:653-660.

6.

6. Ervasti T, Knuuttila M, Pohjamo L, Haukipuro K. Relation between control of diabetes and gingival bleeding. J Periodontol 1985;56:154-157.

7.

7. Cutler CW, Machen RL, Jotwani R, Iacopino AM. Heightened gingival inflammation and attachment loss in type 2 diabetics with hyperlipidemia. J Periodontol 1999;70:1313-1321.

8.

8. Shlossman M, Knowler WC, Pettitt DJ, Genco RJ. Type 2 diabetes mellitus and periodontal disease. J Am Dent Assoc 1990;121:532-536.

9.

9. Emrich LJ, Shlossman M, Genco RJ. Periodontal disease in non-insulin-dependent diabetes mellitus. J Periodontol 1991;62:123-131.

10.

10. Taylor GW, Burt BA, Becker MP, et al. Non-insulin dependent diabetes mellitus and alveolar bone loss progression over 2years. J Periodontol 1998;69:76-83.

11.

11. Barnett ML, Baker RL, Yancey JM, MacMillan DR, Kotoyan M. Absence of periodontitis in a population of insulin-dependent diabetes mellitus (IDDM) patients. J Periodontol 1984;55:402-405.

12.

12. Tervonen T, Karjalainen K, Knuuttila M, Huumonen S. Alveolar bone loss in type 1 diabetic subjects. J Clin Periodontol 2000;27:567-571.

13.

13. Tsai C, Hayes C, Taylor GW. Glycemic control of type 2 diabetes and severe periodontal disease in the US adult population. Community Dent Oral Epidemiol 2002;30:182-192.

14.

14. Sadeghi R, Taleghani F, Mohammadi S, Zohri Z. The Effect of Diabetes Mellitus Type I on Periodontal and Dental Status. J Clin Diagn Res 2017;11:ZC14-ZC17.

15.

15. Sabharwal A, Gomes-Filho IS, Stellrecht E, Scannapieco FA. Role of periodontal therapy in management of common complex systemic diseases and conditions: An update. Periodontol 2000 2018;78:212-226.

16.

16. Fu X, Liu B, Sun J, et al. Perturbation of mitochondrial dynamics links to the aggravation of periodontitis by diabetes. J Histotechnol 2023:1-12.

17.

17. Zang Y, Song JH, Oh SH, et al. Targeting NLRP3 Inflammasome Reduces Age-Related Experimental Alveolar Bone Loss. J Dent Res 2020;99:1287-1295.

18.

18. Lalla E, Lamster IB, Feit M, Huang L, Schmidt AM. A murine model of accelerated periodontal disease in diabetes. J Periodontal Res 1998;33:387-399.

19.

19. Lalla E, Lamster IB, Stern DM, Schmidt AM. Receptor for advanced glycation end products, inflammation, and accelerated periodontal disease in diabetes: mechanisms and insights into therapeutic modalities. Ann Periodontol 2001;6:113-118.

20.

20. Shami A, Gustafsson R, Kalamajski S, et al. Fibromodulin deficiency reduces low-density lipoprotein accumulation in atherosclerotic plaques in apolipoprotein E-null mice. Arterioscler Thromb Vasc Biol 2013;33:354-361.

21.

21. Goldberg M, Septier D, Oldberg A, Young MF, Ameye LG. Fibromodulin-deficient mice display impaired collagen fibrillogenesis in predentin as well as altered dentin mineralization and enamel formation. J Histochem Cytochem 2006;54:525-537.

22.

22. Ballato E, Deepika F, Prado M, et al. Circulating osteogenic progenitors and osteoclast precursors are associated with longterm glycemic control, sex steroids, and visceral adipose tissue in men with type 2 diabetes mellitus. Front Endocrinol (Lausanne)2022;13:936159.

23.

23. Ehnert S, Freude T, Ihle C, et al. Factors circulating in the blood of type 2 diabetes mellitus patients affect osteoblast maturation - description of a novel in vitro model. Exp Cell Res 2015;332:247-258.

24.

24. Carnevale V, Romagnoli E, D'Erasmo L, D'Erasmo E. Bone damage in type 2 diabetes mellitus. Nutr Metab Cardiovasc Dis 2014;24:1151-1157.

25.

25. Li J, He W, Liao B, Yang J. FFA-ROS-P53-mediated mitochondrial apoptosis contributes to reduction of osteoblastogenesis and bone mass in type 2 diabetes mellitus. Sci Rep 2015;5:12724.

26.

26. Boyce BF, Xing L. Biology of RANK, RANKL, and osteoprotegerin. Arthritis Res Ther 2007;9 Suppl 1:S1.

27.

27. Badiger AB, Gowda TM, Chandra K, Mehta DS. Bilateral Interrelationship of Diabetes and Periodontium. Curr Diabetes Rev 2019;15:357-362.

28.

28. Li Z, Zheng Z, Pathak JL, et al. Leptin-deficient ob/ob mice exhibit periodontitis phenotype and altered oral microbiome. J Periodontal Res 2023;58:392-402.

29.

29. Sassi F, Buondonno I, Luppi C, et al. Type 2 diabetes affects bone cells precursors and bone turnover. BMC Endocr Disord 2018;18:55.

30.

30. Rashad NM, El-Shal AS, Shalaby SM, Abdel-Nour HM, Sarhan WM. Osteoprotegerin expression and serum values in obese women with type 2 diabetes mellitus. Mol Biol Rep 2021;48:7095-7104.

31.

31. Zhang L, Ding Y, Rao GZ, Miao D. Effects of IL-10 and glucose on expression of OPG and RANKL in human periodontal ligament fibroblasts. Braz J Med Biol Res 2016;49:e4324.

logo

논문 투고
OA 정책