- P-ISSN 1010-0695
- E-ISSN 2288-3339
- 권한신청
- P-ISSN1010-0695
- E-ISSN2288-3339
논문 상세
Home > 논문 상세
Effect of Samul-tang(Siwu-tang)on Procollagen Synthesis in Cultured Murine Hepatic Non-parenchymal Cells
대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2003, v.24 no.4, pp.120-126
(경희대학교)
(경희대학교)
(경희대학교)
(경희대학교)
(경희대학교)
Young-Chul,
K.
,
Jang-Hoon,
L.
,
&
Hong-Jung,
W.
(2003). . 대한한의학회지, 24(4), 120-126.
- 다운로드 수
- 조회수
Abstract
OBJECT : This study was done to evaluate the inhibitory effect of Samul-tang(Siwu-tang) on collagen production by cultured murine hepatic non-parenchymal cells. METHODS : Hepatic non-parenchymal cells were cultured from normal Spraque-Dawley rats and established in primary cell culture on uncoated plastic culture plates. The Samul-tang(Siwu-tang) was treated into the cell culture media for 72 hours and the cells were harvested for the analysis. Analyses were done on cell proliferation, [3H]thymidine incorporation assay and procollagen type 1 C-peptide.RESULTS : The cultured cells resembled the fibroblasts in shape and produced procollagen which is consistent to fibrogenesis in vivo. The proliferation of the non-parenchymal cells was inhibited slightly and the [3H]thymidine incorporation assay showed dose-dependent decrease by Samul-tang(Siwu-tang) treatment. The production of procollagen type 1 C-peptide was decreased by low-concentration treatment of the Samul-tang(Siwu-tang), but increased by high-concentration treatment.CONCLUSION : It seemed that the cells were responding to the Samul-tang(Siwu-tang) in low-concentration thus producing less collagen. But, when the drug was administered with high concentration enough to have excessive stimulation to cells, it seemed that the activated cells might overly produce procollagen, precursor of collagen, thus aggravating fibrosis of the liver. So, it is considered that the proper concentration of the Samul-tang(Siwu-tang) is important when treating patients with liver cirrhosis based on the patients' status.------
- keywords
- Samul-tang(Siwu-tang), liver cirrhosis, procollagen, non-parenchymal cell, fibrosis, Samul-tang(Siwu-tang), liver cirrhosis, procollagen, non-parenchymal cell, fibrosis
- 다운로드 수
- 조회수
- 0KCI 피인용수
- 0WOS 피인용수
권호 내 다른 논문
- The Relative Risk Assessment of Leptin for Stroke in Korea
- Correlation Among Obesity Factors in Stroke in Korea
- Effect of TongBiYeum(TBY) on the Fatty Liver
- Risk Assessment of Smoking for Ischemic Stroke in Koreans
- Study on the Relationship between Iris Constitution and Apolipoprotein E Gene Polymorphism
- Modulation of Corydalis tuber on Glycine-induced Ion Current in Acutely Dissociated Rat Periaqueductal Gray Neuron
- Effect of Drynariae Rhizoma on the Proliferation of Human Bone Cells
- Effect of TongbBiEum(TBE) on Hyperlipidemia Induced by a Sucrose-rich Diet
- The Effect of a Cooperative System of Oriental and Western Medicine in the Treatment of Allergic Rhinitis
- Recovery Effects from Oxidative Cell Damage by So-Hap-Hyang-Won on Bovine Aortic Endothelial Cells(BAEC)
- The Inhibition Effect of Water Extract of Acanthopanax senticousus Harms Roots on the 5-HT Induced Vasocontraction in Rat
- The Effect of Rheum palmatum L. and Rheum undulatum L. on Rat Thoracic Aorta and Abdominal Aorta
- Incomplete Relationship between Dominant Power of Electrogastrography and Gastric Myoelectrical Activity in patients with Functional Dyspepsia
- Study on Individual and Combined Relationship of Angiotensin Converting Enzyme,Apolipoprotein E and Angiotensinogen Genes Polymorphism in Patients with Ischemic Cerebrovascular Disease
- Study on the Relationship between Polymorphism in Apolipoprotein E Gene and Korean Ischemic Cerebrovascular Disease Patients
- Effect of Samul-tang(Siwu-tang)on Procollagen Synthesis in Cultured Murine Hepatic Non-parenchymal Cells
- Acupuncture Suppresses Intrastriatal Hemorrhage-Induced Neuronal Cell Death and Proliferation in Rats
- The Effects of Live Leech(Hirudo Medicinalis)Therapy on Diabetic Foot : a Clinical Case Report
- A Clinical Study of Oriental Medical Treatment on a Patient with Polyneuropathy
- Clinical Observation on Oculomotor Nerve Palsy Treated by Moxibustion
- more
추천 논문
학술지 홈페이지 이용 환경은 크롬 브라우저 사용을 권장합니다.