- P-ISSN 1010-0695
- E-ISSN 2288-3339
- Apply for Authority
- P-ISSN1010-0695
- E-ISSN2288-3339
Article Detail
Home > Article Detail
Effect of Drynariae Rhizoma on the Proliferation of Human Bone Cells
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2003, v.24 no.4, pp.43-53
Bu-Tae,
L.
, &
Ji-Cheon,
J.
(2003). Effect of Drynariae Rhizoma on the Proliferation of Human Bone Cells. Journal of Korean Medicine, 24(4), 43-53.
- Downloaded
- Viewed
Abstract
Drynariae Rhizoma (DR), an herbal medicine known for its effect to purify blood quality and improve circulation, frequently appears as the main ingredient in prescriptions for bone injuries. Currently, how pharmacologically it contributes to the reformation of bone is unclear. In the present study, the effect of the aqueous extract of DR on bone cells was investigated in vitro for the first time. The human osteoprecursor cells (OPC-1) were incubated in the medium with different concentrations of the aqueous extract of DR and the cell proliferation was studied. When the concentration of DR aqueous extract was <120 μg/ml, the proliferation of OPC-1 was enhanced. However, the proliferation of OPC-1 was inhibited by DR extract with the concentrations >250 μg/ml. Under most treatments, the cells presented very pale expression for cyclooxygenase-2 (Cox 2) protein; slightly intensified band showed at the highest DR concentration, 1.0 mg/ml during the course of culture. From the results, it was cloncluded that the aqueous extract of DR was found to directly stimulate the proliferation, alkaline phosphatase (ALP) activity, protein secretion and particularly type I collagen synthesis of OPC-1 at dose-dependent manner.
- keywords
- Drynariae Rhizoma, human osteoprecursor cells, alkaline phosphatase, collagen type I
- Downloaded
- Viewed
- 0KCI Citations
- 0WOS Citations
Other articles from this issue
- The Relative Risk Assessment of Leptin for Stroke in Korea
- Correlation Among Obesity Factors in Stroke in Korea
- Effect of TongBiYeum(TBY) on the Fatty Liver
- Risk Assessment of Smoking for Ischemic Stroke in Koreans
- Study on the Relationship between Iris Constitution and Apolipoprotein E Gene Polymorphism
- Modulation of Corydalis tuber on Glycine-induced Ion Current in Acutely Dissociated Rat Periaqueductal Gray Neuron
- Effect of Drynariae Rhizoma on the Proliferation of Human Bone Cells
- Effect of TongbBiEum(TBE) on Hyperlipidemia Induced by a Sucrose-rich Diet
- The Effect of a Cooperative System of Oriental and Western Medicine in the Treatment of Allergic Rhinitis
- Recovery Effects from Oxidative Cell Damage by So-Hap-Hyang-Won on Bovine Aortic Endothelial Cells(BAEC)
- The Inhibition Effect of Water Extract of Acanthopanax senticousus Harms Roots on the 5-HT Induced Vasocontraction in Rat
- The Effect of Rheum palmatum L. and Rheum undulatum L. on Rat Thoracic Aorta and Abdominal Aorta
- Incomplete Relationship between Dominant Power of Electrogastrography and Gastric Myoelectrical Activity in patients with Functional Dyspepsia
- Study on Individual and Combined Relationship of Angiotensin Converting Enzyme,Apolipoprotein E and Angiotensinogen Genes Polymorphism in Patients with Ischemic Cerebrovascular Disease
- Study on the Relationship between Polymorphism in Apolipoprotein E Gene and Korean Ischemic Cerebrovascular Disease Patients
- Effect of Samul-tang(Siwu-tang)on Procollagen Synthesis in Cultured Murine Hepatic Non-parenchymal Cells
- Acupuncture Suppresses Intrastriatal Hemorrhage-Induced Neuronal Cell Death and Proliferation in Rats
- The Effects of Live Leech(Hirudo Medicinalis)Therapy on Diabetic Foot : a Clinical Case Report
- A Clinical Study of Oriental Medical Treatment on a Patient with Polyneuropathy
- Clinical Observation on Oculomotor Nerve Palsy Treated by Moxibustion
- more
Recommanded Articles
This website recommended the use the Chrome browser for journal website.