- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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The Inhibition Effect of Water Extract of Acanthopanax senticousus Harms Roots on the 5-HT Induced Vasocontraction in Rat
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2003, v.24 no.4, pp.82-86
Hyung-Hwan,
K.
, Duk-Kyun,
A.
, Chang-Soo,
Y.
, &
Ho-Young,
C.
(2003). The Inhibition Effect of Water Extract of Acanthopanax senticousus Harms Roots on the 5-HT Induced Vasocontraction in Rat. Journal of Korean Medicine, 24(4), 82-86.
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Abstract
Objective : We have examined the inhibition of 5-Hydroxytryptamine (5-HT) induced vasocontraction to the water extract of Acanthopanax senticusus Harms. roots (ASR) on rat thoracic aorta and mesenteric artery with and without endothelium.Methods : Segments of thoracic aorta and mesenteric artery obtained from rats immediately after delivery were mounted in organ baths superfused on a polygraph.Results : We found that the thoracic aorta segments responded to the water extract of ASR with a dose-dependent and concentration-dependent vasorelaxation. 5-HT produced a concentration-dependent contraction of the thoracic aorta and mesenteric artery. At high concentration, ASR, the inhibition response were 93.7% (Jang-su), 93.5% (Heok-ryong-kang-sung), 92.8% (Back-doo mountain), and 83.5% (Yeon-byun) of the maximum 5-HT induced contraction. At high concentration ASR, the relaxational response at thoracic aorta and mesenteric artery with endothelium were 95.2% and 94.6%. without were 93.5% and 92.5% of the maximum 5-HT induced contraction.Conclusions : In conclusion, the effect of water extract of ASR had potent inhibition at 5-HT and the effect of ASR in isolated thoracic aorta and mesenteric artery showed dose-dependent inhibition but endothelium-independent response.
- keywords
- Acanthopanax senticosus Harms, 5-Hydroxytryptamine, thoracic aorta, mesenteric artery., Acanthopanax senticosus Harms, 5-Hydroxytryptamine, thoracic aorta, mesenteric artery.
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