- P-ISSN 1010-0695
- E-ISSN 2288-3339
Background and Purposes: Smoking is a well-known risk factor for ischemic stroke. It may contribute to stroke by inducing the aggregation of platelets formation of atheroma, reducing cerebral blood flow, and increasing fibrinogen. However, the relative risk varied according to the different ethnics and areas. Therefore, we performed this study to assess the risk of smoking for ischemic stroke in Korea. Methods: Cigarette smoking habit was studied in 308 patients with ischemic stroke and in 348 age-, sex-matched control subjects who had no history of stroke using case control methods. In multiple logistic regression analysis, smoking had a significant value of odds ratio adjusted for hypertension, diabetes mellitus, and hyperlipidemia. Results: The adjusted odds ratio (AOR) and 95% was significant in the medium smokers (AOR, 1.92; 95% CI, 1.11 to 3.33: p < 0.05) and heavy smokers (AOR, 2.80; 95% CI, 1.64 to 4.78: p < 0.05). Furthermore, the OR increased higher in hypertensive subjects than in normotensive subjects compared to non-smokers (AOR, 1.98; 95% CI, 1.01 to 3.85: p < 0.05).Conclusions: Our findings suggest that smoking is an independent risk factor for ischemic stroke in Korea.