- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Effect of Samul-tang(Siwu-tang)on Procollagen Synthesis in Cultured Murine Hepatic Non-parenchymal Cells
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2003, v.24 no.4, pp.120-126
Young-Chul,
K.
, Jang-Hoon,
L.
, &
Hong-Jung,
W.
(2003). Effect of Samul-tang(Siwu-tang)on Procollagen Synthesis in Cultured Murine Hepatic Non-parenchymal Cells. Journal of Korean Medicine, 24(4), 120-126.
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Abstract
OBJECT : This study was done to evaluate the inhibitory effect of Samul-tang(Siwu-tang) on collagen production by cultured murine hepatic non-parenchymal cells. METHODS : Hepatic non-parenchymal cells were cultured from normal Spraque-Dawley rats and established in primary cell culture on uncoated plastic culture plates. The Samul-tang(Siwu-tang) was treated into the cell culture media for 72 hours and the cells were harvested for the analysis. Analyses were done on cell proliferation, [3H]thymidine incorporation assay and procollagen type 1 C-peptide.RESULTS : The cultured cells resembled the fibroblasts in shape and produced procollagen which is consistent to fibrogenesis in vivo. The proliferation of the non-parenchymal cells was inhibited slightly and the [3H]thymidine incorporation assay showed dose-dependent decrease by Samul-tang(Siwu-tang) treatment. The production of procollagen type 1 C-peptide was decreased by low-concentration treatment of the Samul-tang(Siwu-tang), but increased by high-concentration treatment.CONCLUSION : It seemed that the cells were responding to the Samul-tang(Siwu-tang) in low-concentration thus producing less collagen. But, when the drug was administered with high concentration enough to have excessive stimulation to cells, it seemed that the activated cells might overly produce procollagen, precursor of collagen, thus aggravating fibrosis of the liver. So, it is considered that the proper concentration of the Samul-tang(Siwu-tang) is important when treating patients with liver cirrhosis based on the patients' status.------
- keywords
- Samul-tang(Siwu-tang), liver cirrhosis, procollagen, non-parenchymal cell, fibrosis, Samul-tang(Siwu-tang), liver cirrhosis, procollagen, non-parenchymal cell, fibrosis
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