- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Effect of TongbBiEum(TBE) on Hyperlipidemia Induced by a Sucrose-rich Diet
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2003, v.24 no.4, pp.54-63
Yong-Seong,
O.
, Yoon-Sik,
K.
, &
In-Chan,
S.
(2003). Effect of TongbBiEum(TBE) on Hyperlipidemia Induced by a Sucrose-rich Diet. Journal of Korean Medicine, 24(4), 54-63.
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Abstract
Objectives : This study was aimed to elucidate the effects of TBE on hyperlipidemia. Methods : We studied the effects of TBE on hyperlipidemia through gene expressions related with lipid metabolism, serum triglyceride as well as total and HDL-cholesterol levels, and perceived histological changes. Results : The present studies demonstrate that TBE can reduce the rise in plasma cholesterol, TG levels induced by a high cholesterol diet and also reverse pre-established hypercholesterolemia and hypertriglycemia. In TBE group total cholesterol levels decreased, TG levels decreased, but HDL-cholesterol levels decreased. In the analysis of absolute and relative liver weight, TBE inhibited the weight gain induced by high cholesterol diet. In the histological observations, lipid droplet and apoptotic change in the TBE treated group were less compared with control group. In the serum biochemical analysis, the difference of serum AST and ALT changes among groups was not shown, but TG and total cholesterol levels were less and HDL level decreased compared with control group. In the gene expression related with TG and cholesterol metabolism, DGAT decreased slightly but ACAT more decreased as compared with control and Lipidil group. Conclusion : From this study, we can infer that TBE possesses hypolipidemic effect by inhibiting the intestinal absorption and storage of exogenous and endogenous cholesterol.
- keywords
- hyperlipidemia, TongBiEum, TBE, triglyceride, TG
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