- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Review of Biophoton of human beings -domestic papers
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2006, v.27 no.2, pp.70-85
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(2006). Review of Biophoton of human beings -domestic papers. Journal of Korean Medicine, 27(2), 70-85.
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Abstract
Objectives : This study was examined for the neuroprotective effect of Hyulbuchookautang(血府逐瘀湯, HBCAT) against neural damage following focal cerebral infarction. Methods : Sprague-Dawley Rats induced focal cerebral infarction by temporal middle cerebral artery occlusion(MCAO). The rats were divided into 2 groups. We treated extract of HBCAT to one group after operation (sample group), and the other group wasn't treated after operation(control group). We observed neurological scores and TTC-stained Infarct Area, total infarct volume in brain sections and Bax-positive neurons, HSP70- positive neurons in brain regions. Results : HBCAT treatment at 3 days after MCAO reduced neurological scores induced by MCAO. HBCAT treatment at 5 days after MCAO reduced TTC-stained Infarct Area in brain sections induced by MCAO. HBCAT treatment at 5 days after MCAO reduced total infarct volume in brain sections induced by MCAO. HBCAT treatment after MCAO reduced Bax-positive neurons in cortex infarct core and cortex infarct penumbra and caudo-putamen of brain regions induced by MCAO. HBCAT treatment after MCAO reduced HSP70- positive neurons in cortex infarct penumbra of brain regions induced by MCAO. Conclusions : These results suggest that HBCAT has a neuroprotective effect against focal cerebral ischemia.
- keywords
- Hyulbuchookautang(血府逐瘀湯, HBCAT), middle cerebral artery occlusion(MCAO), neuroprotective effect, focal cerebral infarction, Hyulbuchookautang(血府逐瘀湯, HBCAT), middle cerebral artery occlusion(MCAO), neuroprotective effect, focal cerebral infarction
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