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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

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Review of Biophoton of human beings -domestic papers

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2006, v.27 no.2, pp.70-85
조은희 (동의대학교 한방병원)
권정남 (부산대학교)
김영균 (동의대학교)
조은희, 권정남, & 김영균. (2006). . 대한한의학회지, 27(2), 70-85.
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Abstract

Objectives : This study was examined for the neuroprotective effect of Hyulbuchookautang(血府逐瘀湯, HBCAT) against neural damage following focal cerebral infarction. Methods : Sprague-Dawley Rats induced focal cerebral infarction by temporal middle cerebral artery occlusion(MCAO). The rats were divided into 2 groups. We treated extract of HBCAT to one group after operation (sample group), and the other group wasn't treated after operation(control group). We observed neurological scores and TTC-stained Infarct Area, total infarct volume in brain sections and Bax-positive neurons, HSP70- positive neurons in brain regions. Results : HBCAT treatment at 3 days after MCAO reduced neurological scores induced by MCAO. HBCAT treatment at 5 days after MCAO reduced TTC-stained Infarct Area in brain sections induced by MCAO. HBCAT treatment at 5 days after MCAO reduced total infarct volume in brain sections induced by MCAO. HBCAT treatment after MCAO reduced Bax-positive neurons in cortex infarct core and cortex infarct penumbra and caudo-putamen of brain regions induced by MCAO. HBCAT treatment after MCAO reduced HSP70- positive neurons in cortex infarct penumbra of brain regions induced by MCAO. Conclusions : These results suggest that HBCAT has a neuroprotective effect against focal cerebral ischemia.

keywords
Hyulbuchookautang(血府逐瘀湯, HBCAT), middle cerebral artery occlusion(MCAO), neuroprotective effect, focal cerebral infarction, Hyulbuchookautang(血府逐瘀湯, HBCAT), middle cerebral artery occlusion(MCAO), neuroprotective effect, focal cerebral infarction


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