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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

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Loperamide로 억제된 위장관 운동에 대한 사관혈의 자침효과: 무작위배정, 단일눈가림, 교차설계, 대조 임상시험

A Crossover Clinical Trial to Determine the Effect of Siguan(Four Gates) Points on Gastrointestinal Motility Suppressed by Loperamide Administration

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2008, v.29 no.1, pp.1-6
오달석 (한국한의학연구원)
정소영 (한국한의학연구원)
김애란 (한국한의학연구원)
강위창 (대전대학교)
박지은 (한국한의학연구원)
구창모 (한국한의학연구원)
최준용 (부산대학교)
정희정 (한국한의학연구원)
최선미 (한국한의학연구원)
손창규 (대전대학교)
오달석, 정소영, 김애란, 강위창, 박지은, 구창모, 최준용, 정희정, 최선미, & 손창규. (2008). Loperamide로 억제된 위장관 운동에 대한 사관혈의 자침효과: 무작위배정, 단일눈가림, 교차설계, 대조 임상시험. 대한한의학회지, 29(1), 1-6.
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Abstract

Objective:To investigate the therapeutic effect of manual acupuncture at Siguan (four gates, bilateral LI4 and LR3) on suppression of gastrointestinal motility. Methods:A single blind, randomized, sham-acupuncture controlled, crossover study was conducted. Twenty healthy male subjects were admitted at hospital, and gastrointestinal motility suppression was induced by loperamide administration. Just after intake of 20 radio-markers, four gates or sham acupoint treatments were administered every 12 hours, 4 times over 48 hours. Gastrointestinal motility was evaluated by radiographic distribution of the radio- markers at stomach or ileum, ascending, transverse, descending colon, sigmoid/rectum, and outside body at serial time points (0, 6, 12, 24, and 48 h). Results:Four gates acupuncture activated gastrointestinal movement as evidenced by significantly changed distribu- tionof radio-makers at 6, 12, and 48 hours (P < 0.0001, P = 0.001, and P = 0.03, respectively) in Cochran-Mantel- Haenszel statistics. No serious adverse events occurred in either group. Conclusions:This study showed a scientific clinical relevance of four gates acupuncture to gastrointestinal disorders.

keywords
Siguan (four gates), acupuncture, LI4, LR3, gastrointestinal motility


참고문헌

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3. Jang-Woo Shin, Jin-Young Son, Yun-Kyoung Yim, Sun Mi Choi, Sung-Tae Koo, Chang-Gue Son. Acupuncture on Siguan points (LI4 and LR3) restores Loperamide/Scopolamine-induced intestinal immotility in mice. Korean J of Orient Med 2006;27:146-54.

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4. Yim YK, Kang WC, Cho JH, Shin JW, Lee NH, Choi SM, Koo ST, Park KS, Son CG. Crossover clinical trial to determine the effect of manual acupuncture at Siguan points (bilateral LI4 and LR3) on intestinal motility in healthy subjects. Am J Chin Med 2007;35 :209-18.

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