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- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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A Crossover Clinical Trial to Determine the Effect of Siguan(Four Gates) Points on Gastrointestinal Motility Suppressed by Loperamide Administration
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2008, v.29 no.1, pp.1-6
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(2008). A Crossover Clinical Trial to Determine the Effect of Siguan(Four Gates) Points on Gastrointestinal Motility Suppressed by Loperamide Administration. Journal of Korean Medicine, 29(1), 1-6.
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Abstract
Objective:To investigate the therapeutic effect of manual acupuncture at Siguan (four gates, bilateral LI4 and LR3) on suppression of gastrointestinal motility. Methods:A single blind, randomized, sham-acupuncture controlled, crossover study was conducted. Twenty healthy male subjects were admitted at hospital, and gastrointestinal motility suppression was induced by loperamide administration. Just after intake of 20 radio-markers, four gates or sham acupoint treatments were administered every 12 hours, 4 times over 48 hours. Gastrointestinal motility was evaluated by radiographic distribution of the radio- markers at stomach or ileum, ascending, transverse, descending colon, sigmoid/rectum, and outside body at serial time points (0, 6, 12, 24, and 48 h). Results:Four gates acupuncture activated gastrointestinal movement as evidenced by significantly changed distribu- tionof radio-makers at 6, 12, and 48 hours (P < 0.0001, P = 0.001, and P = 0.03, respectively) in Cochran-Mantel- Haenszel statistics. No serious adverse events occurred in either group. Conclusions:This study showed a scientific clinical relevance of four gates acupuncture to gastrointestinal disorders.
- keywords
- Siguan (four gates), acupuncture, LI4, LR3, gastrointestinal motility
Reference
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