Article Detail

Home > Article Detail
  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

Study of Silent Infarct in First-ever Cerebral Infarction Patients Treated in an Oriental Medical Hospital.

Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2008, v.29 no.1, pp.192-199














  • Downloaded
  • Viewed

Abstract

Objective:Silent infarct is more common in healthy elderly people and seems associated with risk of future stroke. However, the prevalence and risk factors of silent infarct are unclear. We investigated the prevalence and risk factors of silent infarct. Methods:56 first-ever cerebral infarct patients were enrolled in this study. CT images were made of all 56 patients. We divided them into two groups according to the presence of silent infarcts and comparedage, sex, education period, WHR, hypertension, diabetes mellitus, hyperlipidemia, smoking, numbness and weakness of thumb and index finger, neck stiffness, facial spasm, and blepherospasm. Result:Silent infarcts were found in 24 patients(43%). Most infarcts(48%) were located in basal ganglia. Age, sex, education period, WHR, numbness and weakness of thumb and index finger, neck stiffness, facial spasm, and blepherospasm were similar between the two groups. Diabetes mellitus, hyperlipidemia, and smoking were higher in the silent infarct group. Hypertension was higher in the non-silent infarct group. Conclusion:The prevalence of silent infarct in first-ever cerebral infarction patients was 43% and diabetes mellitus, hyperlipidemia, and smoking were higher in silent infarct patients.

keywords
Silent infarct, first-ever cerebral infarction


Reference

1

1. Masuda J, Nabika T, Notsu Y : Silent stroke: pathogenesis, genetic factors and clinical impl- ications as a risk factor. Curr Opin Neurology. 14:77-82. 2001.

2

2. Vermeer SR, Prins ND, den Heijer T, Hofman A, Koudstaal PJ, Breteler MMB : Silent brain infarcts and the risk of dementia and cognitive decline. N Engl J Med. 348:1215-22. 2003.

3

3. De Groot JC, de Leeuw FE, Oudkerk M, van Gijn J, Hofman A, Jolles J, Breteler MM : Periventricular cerebral white matter lesions predict rate of cognitive decline. Ann Neurol. 52:335-41. 2002.

4

4. Vermeer SE, Hollander M, van Dijk EJ, Hofman A, Koudstaal PJ, Breteler MM;Rott- erdam Scan Study : silent brain infarcts and white matter lesions increase stroke risk in the general population:the Rotterdam Scan Study. Stroke. 34:1126-9. 2003.

5

5. Bernick C, Kuller L, Dulberg C, Longstreth WT Jr, Manolio T, Beauchamp N, Price T;Cardiovascular Health Study Collaborative Research Group : Silent MRI infarcts and the risk of future stroke:the Cardiovascular Health Study. Neurology. 57:1222-9. 2001.

6

6. Fujikawa T : Asymptomatic cerebral infarction and depression:the concept of vascular depression. Seishin Shinkeiqaku Zasshi. 106(4):421-30. 2004.

7

7. Kario K, Shimada K, Schwartz JE, Matsuo T, Hoshide S, Pickering TG : Silent and clinically overt stroke in older Japanese subjects with white-coat and sustained hypertension. J Am Coll Cardiol. 38:238-45. 2001.

8

8. Kobayashi S, Okada K, Koide H, Bokura H, Yamaguchi S : Subcortical silent brain infarction as a risk factor for clinical stroke. Stroke. 28:1932-9. 1997.

9

9. Price TR, Manolio TA, Kronmal RA, Kitner SJ, Yue MC, Robbins J, Anton-Culver H, O'Leary DH : Silent brain infarction on magnetic resonance imaging and neurological abnormalities in community-dwelling older adults:the Cardi- ovascular Health Study. Stroke. 28:1158-64. 1997.

10

10. Vermeer SE, Koudstaal PJ, Oudkerk M, Hofman A, Breteler MM : Prevalence and risk factors of silent brain infarcts in the population- based:Rotterdam Scan Study. Stroke. 33:1179 -80. 2002.

11

11. 윤신구, 방차옥, 성기범, 박형국, 신현길 : 첫 번째 뇌졸중 환자에서 무증상 뇌경색:뇌자기공명영상 소견과 위험인자. 대한신경과학회지. 14(1):42-5. 1996.

12

12. Shimada K, Kawamoto A, Matsubayashi K, Nishinaga M, Kimura S, Ozawa T : Diurnal blood pressure variations and silent cerebrova- scular damage in elderly patients with hyperte- nsion. J Hypertension. 10:875-8. 1992.

13

13. Kario K, Matsuo T, Kobayashi H, Imiya M, Matsuo M, Shimada K : Nocturnal fall of blood pressure and silent cerebrovascular damage in elderly hypertensive patients. Adva- nced silent cerebrovascular damage in extreme dippers. J Hypertension. 27:130-5. 1996.

14

14. Eguchi K, Kario K, Shimada K : Greater impact of coexistence of hypertension and diabetes on silent cerebral infarcts. Stroke. 34: 2471-4. 2003.

15

15. Giele JL, Witkamp TD, Mali WP, van der Graff Y : Silent brain infarcts in patients with Manifest vascular Disease. Stroke. 35:742-6. 2004.

16

16. Eguchi K, Kario K, Hoshide S, et al. : Smoking is associated with silent cerebrovascular disease in a high-risk Japanese community- dwelling population. Hypertens Res. 27:747- 54. 2004.

17

17. Kinney TR, Sleeper LA, Wang WC, Zimmerman RA, Pegelow CH, Ohene-Frempong K, et al. : Silent cerebral infarcts in sickle cell anemia:a risk factor analysis. The Cooperative Study of Sickle Cell Disease. Pediatrics. 103:640-5. 1999.

18

18. Kwon HM, Kim BJ, Lee SH, Choi SH, Oh BH, Yoon BW : Metabolic syndrome as an independent risk factor of silent brain infarction in healthy people. Stroke. 37(2):466-70. 2006.

19

19. Siachos T, Vanbakel A, Feldman DS, Uber W, Simpson KN, Pereira N : Silent strokes in patients with heart failure. Journal of cardiac failure. 11(7):485-9. 2005.

20

20. Liebetrau M, Steen B, Hamann GF, Skooq I : Silent and symptomatic infarcts on cranial computerized tomography in relation to dementia and mortality. Stroke. 35(8):1816- 20. 2004.

21

21. 안일회, 양경석 : 中風前兆症에 關한 東西醫學的 考察. 원광한의학회지. 6(1):65-83. 1996.

22

22. 정승현, 신길조, 이원철 : 中風前兆症에 對한 考察. -TCD의 활용을 중심으로-. 한방성인 병학회지. 2(1):74-89. 1996.

23

23. 안영기, 차상현 : 東洋醫學의 中風前兆症에 對한 文獻的 考察. 동서의학회지. 10(3):83-94. 1985.

24

24. 서창훈, 권정남 : 腦梗塞患者의 中風前兆症에 대한 臨床的 考察. 대한한방내과학회지. 19(1): 134-43. 1998.

25

25. 심동석, 박성경, 김중석, 유지연, 김범수, 정소령, 이광수, 김영인 : 정상 성인에서 무증상 뇌경색의 유병률과 위험인자:단일기관연구. 대한신경과학회지. 23(3):303-6. 2005.

26

26. Mounier-Vehier F, Leys D, Rondepierre P, Godefroy O, Pruvo JP : Silent infarcts in patients with ischemic stroke are related to age and size of the left atrium. Stroke. 24(9): 1347-51. 1993.

27

27. Corea F, Tambasco N, Luccioli R, Ciorba E, Parnetti L, Gallai V : Brain CT-scan in acute stroke patients: silent infarcts and relation to outcome. Clinical and experimental hypertension. 24(7-8):669-76. 2002.

28

28. Vermeer SE, Den heijer, Koudstaal PJ, Oudkerk M, Hofman A, Breteler MM : Incidence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study. Stroke. 34:392-6. 2003.

29

29. Uehara T, Tabuchi M, Mori E : Risk factors for silent cerebral infarcts in subcortical white matter and basal ganglia. Stroke. 30:378-82. 1999.

30

30. Hoshide S, Kario K, Mitsuhashi T, et al. : Different patterns of silent cerebral infarct in patients with coronary artery disease or hyper- tension. Am J Hypertens. 14:509-15. 2001.

  • Downloaded
  • Viewed
  • 0KCI Citations
  • 0WOS Citations

Other articles from this issue

Recommanded Articles

상단으로 이동

Journal of Korean Medicine