- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Study on Pharmacological Activity of Sipjeondaebotang by Difference in Component Ratio between Astragali Radix and Cinnamomi Cortex
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2008, v.29 no.1, pp.156-166
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(2008). Study on Pharmacological Activity of Sipjeondaebotang by Difference in Component Ratio between Astragali Radix and Cinnamomi Cortex. Journal of Korean Medicine, 29(1), 156-166.
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Abstract
Objective:Pamooltang (PM) and Sipjeondaebotang (SC) are used in Korea to treat many diseases such as sterility, menstrual disorder, and general prostration. We made a comparative study of PM and SC which are different in component ratio between Astragalus membranaceus BUNGE (AC) and Cinnamomum cassia PRESL. (CC). Methods:Anti-oxidation was studied by 1.1.-diphenyl-2-picrylhydrazyl (DPPH) assay and anti-inflammation was investigated by prostaglandin E2 (PGE2) and nitric oxide (NO) inhibition assay. For immune response activities, this study used NO synthesis on RAW 264.7 cells and splenocyte proliferation. Results:The results showed that PM and SC components had no significant effect of anti-oxidation or anti-inflammation. However, we observed their effects upon inducible NO synthesis in Raw 264.7 cells. The SC2 stimulated NO synthesis 11.42±1.36 μM (control; 0.89±0.00 μM). PM and SC components had the effect of immune response which in a dose-dependent manner significantly induced the splenocyte proliferation. The splenocyte proliferation induced by SC2 was higher than others at the concentration of 1, 10, 100, 1000 and 2000 μg/ml. The SC8 was shown to up-regulate IgG, 100 μg/ml 3.3 times, 1000 μg/ml 2.6 times as a control. Conclusions:These results may have important implications for our understanding of the ratios of AC and CC in SC.
- keywords
- Sipjeondaebotang, Pamooltang, NO synthesis, splenocyte
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