- P-ISSN 1010-0695
- E-ISSN 2288-3339
- Apply for Authority
- P-ISSN1010-0695
- E-ISSN2288-3339
Article Detail
Home > Article Detail
Effect of Jasinwhalhyul-tang on MRL/MpJ-Ipr/Ipr Mouse Model with Systemic Lupus Erythematosus
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2008, v.29 no.1, pp.67-84
&
(2008). Effect of Jasinwhalhyul-tang on MRL/MpJ-Ipr/Ipr Mouse Model with Systemic Lupus Erythematosus. Journal of Korean Medicine, 29(1), 67-84.
- Downloaded
- Viewed
Abstract
Objective:The main purpose of this study was to evaluate the effect of Jasinwhalhyul-tang (Zishenhuoxue-tang, JWT) on MRL/MpJ-Ipr/Ipr mouse model with systemic lupus erythematosus. Methods: The effect of JWT on MRL/MpJ-Ipr/Ipr mice that have autoimmune disease similar to SLE in humans was evaluated after JWT per oral in the present study. Mice were administered with Jasinwhalhyul-tang (Zishenh- uoxue-tang, JWT) (80 or 400mg/kg) or distilled water for control group from experimental week 10 for 22 weeks. Results:The amount of erythematosus skin lesion and proteinuria were significantly decreased. The size and weight of cervical lymph nodes and spleen were significantly reduced. The ratio between activated CD3+CD69+ T-cells and undifferentiated CD3+CD4-CD8- T-cells in lymph nodes, spleen and kidney was effectively reduced. The gene expression of TGF-β in spleen and kidney was increased. The amount of anti-dsDNA IgG in blood was decreased. The gene expression of TGF-β in normal mouse spleen cells was increased depending on concentration by treatment of with T cell stimulating agent. In the histological examination of skin and kidney, the amount of infiltration of immune cells involved in the inflammatory response was decreased. Conclusions:According to the above results, JWT should be considered as an applicable therapeutic agent to SLE in clinical practice. Further research is required to investigate other efficacies of JWT on SLE.
- keywords
- SLE, Jasinwhalhyul-tang (Zishenhuoxue-tang, JWT), MRL/MpJ-Ipr/Ipr mouse model
Reference
1
1. Kurtt J. Lssebacher. 해리슨 내과학 서울:정담. 1997:1771-6.
2
2. 이연태 역. 最新免疫學. 서울:集文堂. 1989:398-9.
3
3. 이수곤 역. Pathophysiology로 이해하는 내과학. 서울:정담. 2002:42-6.
4
4. 김세종. 면역학. 서울:고려의학. 1994:219.
5
5. 전국 의과대학 임상교수 편. Color Atlas 임상의학. 서울:한우리. 2000:13-15.
6
6. 李文鎬 외. 內科學. 서울:學林社. 1986:2030-6.
7
7. 유대현. 전신성루푸스의 치료. 류마티스건강학회지. 1996;3(2):240-4.
8
8. Suen JL, Chuang YH, Tsai BY, Yau PM, Chiang BL. Treatment of murine lupus using nucleosomal T cell epitopes identified by bone marrow-derived dendritic cells. Arthritis Rheum. 2004;50(10):3250-9.
9
9. Tsokos GC, Nambiar MP, Tenbrock K, Juang YT. Rewiring the T-cell:signaling defects and novel prospects for the treatment of SLE. Trends Immunol. 2003;24(5):259-63.
10
10. 蔡禹錫. 免疫疾患의 韓方槪念과 治療에 關한 文獻的 考察. 大韓韓醫學會誌. 1990;11(2):54-91.
11
11. 王銅. 現代中醫腎臟病學. 北京:人民衛生出版社. 2003:496-512.
12
12. 안창석, 강계성, 권기록. 전신성홍반성낭창(SLE)환자 1례에 대한 증례보고. 대한약침학회지. 2000;3(2):245-55.
13
13. 김광중, 허수영, 편세현. 全身性紅斑性狼瘡에 對한 中國의 最新傾向. 慶山大學校 韓醫科大學 附設 濟韓東醫學術院 論文集. 1999;4(1): 127-36.
14
14. 정현아, 노석선. 全身性紅斑性狼瘡에 對한 文獻的 考察. 大韓眼耳鼻咽皮膚科學會誌. 2002; 15(1):356-83.
15
15. 이석우, 김한성, 김성훈. 全身性紅斑性狼瘡의 東醫病理 및 治法에 關한 考察. 대한한의학회지. 1995;16(1):51-70.
16
16. 陳以平. 腎病的辨證與辯病治療. 北京:人民衛生出版社. 1997:125-130.
17
17. Fox RR, Witham BA (eds). Genetic polymor- phisms and mutations. In Handbook on Genetically Standardized JAX Mice. Bar Harbor:The Jackson Laboratory. 1997:85-93.
18
18. GU L, Weinreb A, Wang XP, Zack DJ, Quio JH, Weisbart R, Lusis AJ. Genetic determi- nants of autoimmune disease and coronary vasculitis in the MRL-lpr/lpr mouse model of systemic lupus erythematosus. J Immunol. 1998;161:6999-7006.
19
19. Hewicker M, Kromschroder E, Trautwein G. Detection of circulating immune complexes in MRL mice with different forms of glomerul- onephritis. Z Versuchstierkd. 1990;33:149-56.
20
20. Sun Y, Chen HM, Subudhi SK, Chen J, Koka R, Chen L, Fu YX. Costimulatory molecule- targeted antibody therapy of a spontaneous autoimmune disease. Nat Med. 2002;8(12): 1405-13.
21
21. Bednarski JJ, Warner RE, Rao T, Leonetti F, Yung R, Richardson BC, Johnson KJ, Ellman JA, Opipari AW Jr, Glick GD. Attenuation of autoimmune disease in Fas-deficient mice by treatment with a cytotoxic benzodiazepine. Arthritis Rheum. 2003;48(3):757-66.
22
22. 김우철. 통계학개론. 서울:영지문화사. 1990: 177-9.
23
23. 최명애. 병태생리학. 서울:계축문화사. 2001: 61-71.
24
24. 杜鎬京. 東醫腎系學硏究. 서울:慶熙大學校出版局. 1994:181-5.
25
25. 이귀녕. 임상병리화일. 서울:의학문화사. 1993: 1386-7.
26
26. 李惟信. 臨床皮膚科學. 서울:麗文閣. 1992:181.
27
27. 의학교육연수원 편. 가정의학. 서울:서울대학교출판부. 2001:144-5, 306.
28
28. 서울대학교 신장내과 편. 임상 신장학 입문. 서울:신흥메드사이언스. 2002:210-5.
29
29. 醫學敎育硏修院. 藥物療法. 서울:서울대학교출판부. 1994:300-3.
30
30. 박성배, 김재석, 주일, 박재호, 김현철, 이상숙, 김재룡. 전신성홍반성낭창의 임상상 및 병리조직학적 분석. 대한신장학회지. 1989;8(1):94 -105.
31
31. 고영엽. 활동성 전신성홍반성낭창환자에서의 Plasmapheresis를 이용한 치험 1예. 이화의대지. 1990;13(4):443-6.
32
32. Rosner S, Ginzler EM, Diamond HS, Weiner M, Schlesinger M, Fries JF, Wasner C, Medsger TA Jr, Ziegler G, Klippel JH, Hadler NM, Albert DA, Hess EV, Spencer-Green G, Grayzel A, Worth D, Hahn BH, Barnett EV. A multicenter study of outcome in systemic lupus erythematosus. II. Causes of death. Arthritis Rheum. 1982;25(6):612-7.
33
33. Ward MM, Pyun E, Studenski S. Causes of death in systemic lupus erythematosus. Long- term followup of an inception cohort. Arthritis Rheum. 1995;38(10):1492-9.
34
34. Pettersson T, Pukkala E, Teppo L, Friman C. Increased risk of cancer in patients with systemic lupus erythematosus. Ann Rheum Dis. 1992;51(4):437-9.
35
35. 진호준. 전신성 홍반성 낭창 환자의 임상상과 예후 인자에 관한 분석. 서울대학교 대학원 석사학위 논문. 1999.
36
36. 杜鎬京. 東醫腎系學. 서울:東洋醫學硏究院. 1994: 383-5.
37
37. 王云凱. 疾病診治大典. 河北:河北科學技術出版社. 1996:961.
38
38. Drappa J, Brot N, Elcon KB. The Fas protein is expressed at high levels on CD4+CD8+ thymocytes and activated mature lymphocytes in normal mice but not in lupus-prone strain. MRL lpr/lpr. Proceedings of the National Academy of Sciences. 1990;90:10340-4.
39
39. Robak T, Kordek R, Robak E, Bartkowiak J, Biernat W, Liberski P, Blonski J. Langerhans cell histiocytosis in a patient with systemic lupus erythematosus: a clonal disease responding to treatment with cladribine and cyclophos- phamide. Leuk Lymphoma. 2002;43(10):2041 -6.
40
40. Grande JP. Mechanisms of progression of renal damage in lupus nephritis: pathogenesis of renal scarring. Lupus. 1998;7:604-10.
41
41. Janyapoon K, Jivakanont P, Choosang K, Surbrsing R, Charoenying V, Baithong S. Comparative study of anti-double stranded DNA detection by ELISA and Crithidia luciliae immunofluorescence. Southeast Asian J Trop Med Public Health. 2003;34(3):646-50.
- Downloaded
- Viewed
- 0KCI Citations
- 0WOS Citations
Other articles from this issue
- A Crossover Clinical Trial to Determine the Effect of Siguan(Four Gates) Points on Gastrointestinal Motility Suppressed by Loperamide Administration
- Multi-facet Analysis on Validity of Sasang Type Diagnostic Test
- A Study on the Problem about Oriental Treatment Fee Based on Valuation of Resources
- Development of Complementary and Alternative Medicine Curriculum for Undergraduate Students at College of Oriental Medicine
- Acupuncture on ST36 Increases c-Fos Expression in vlPAG of Visceral Pain-induced Mice
- The Inhibitory Effect of Lycii Fructus on LPS-stimulated NF-κB Activation and iNOS Expression in RAW 264.7 Macrophages
- Systematic Analysis of Ginseng-focused Research Worldwide
- Effect of Jasinwhalhyul-tang on MRL/MpJ-Ipr/Ipr Mouse Model with Systemic Lupus Erythematosus
- Study of Effects and Optimum Concentrations of Medical Herb Extracts on Blood Glucose and Serum Lipid in Streptozotocin-Induced Diabetic Rats
- Effect of Polygonati Sibirici Rhizoma on Cell Viability in Human Glioma Cells
- ROS-, RNS-Scavenging and Anti-inflammatory Activities of Mori Fructus
- Skin Humidity Effects of Strontium on Acute Skin Barrier Damage in Hairless Mice
- A Study of the Relationship between Drinking, Smoking and Stress of Workers by Analyzing Heart Rate Variability
- 14The effectiveness of oriental medical therapy compared to oriental-western medical therapy on acute bell’s palsy
- Study on Pharmacological Activity of Sipjeondaebotang by Difference in Component Ratio between Astragali Radix and Cinnamomi Cortex
- The Effect of the Water Extract of Angelica Sinens on Gliosis Repression of Astrocyte after Hypoxic injury
- Therapeutic Effects of Cheonggi-san Extract on NC/Nga Mice with Atopic Dermatitis-like Skin Lesions
- Study of Silent Infarct in First-ever Cerebral Infarction Patients Treated in an Oriental Medical Hospital.
- A Study on Deficiency Syndrome, Excess Syndrome, Reinforcing Method and Reducing Method
- 12 Cases of Strabismus Treated by Acupuncture and Herb Medicine
- more
Recommanded Articles
This website recommended the use the Chrome browser for journal website.