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  • E-ISSN 2288-3339

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당귀가 저산소로 손상된 성상세포의 gliosis 억제에 미치는 영향

The Effect of the Water Extract of Angelica Sinens on Gliosis Repression of Astrocyte after Hypoxic injury

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2008, v.29 no.1, pp.167-178
이승희 (원광대학교)
문성진 (원광대학교)
신진봉 (원광대학교)
허래경 (원광대학교)
성기문 (원광대학교)
양재훈 (원광대학교)
송봉근 (원광대학교)
이승희, 문성진, 신진봉, 허래경, 성기문, 양재훈, & 송봉근. (2008). 당귀가 저산소로 손상된 성상세포의 gliosis 억제에 미치는 영향. 대한한의학회지, 29(1), 167-178.
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Abstract

Object:Gliosis becomes a physical and mechanical barrier to axonal regeneration. Reactive gliosis induced by hypoxic brain injury is involved with up-regulation of CD81 and GFAP. The current study was to examine the effect of the Angelica Sinens on CD81 and GFAP regulation after hypoxic brain injury in the astrocyte. Methods:MTT assay was performed to examine cell viability, and cell based ELISA, western blot and PCR were used to detect the expression of CD81 and GFAP. Results:The following results were obtained: 1. Using ELISA, western blot and PCR from the astrocyte after hypoxic injury, CD81 and GFAP expression was seen to have increased. 2. After the administration of Angelica Sinens extract to astrocyte following hypoxic injury, CD81 and GFAP expression was down regulated significantly. The water extract of Angelica Sinens prevented cell destruction by hypoxic induced with CoCl2. Conclusion:These results indicate that Angelica Sinens could suppress reactive gliosis, which disturbs astrocyte regeneration after hypoxic brain injury by controlling the expression of CD81 and GFAP.

keywords
Angelica Sinens, gliosis, CD81, GFAP, hypoxic brain injury, astrocyte


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