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  • P-ISSN 2233-4203
  • E-ISSN 2093-8950

Determination of Nitarsone in Pork, Egg, Milk, Halibut, Shrimp, and Eel Using QuEChERS and LC-MRM

Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2021, v.12 no.1, pp.11-15
Kim Jin Hee (College of Pharmacy, Dankook University)
Jang Yong Jin (College of Pharmacy, Dankook University)
Kim Dong Yoon (College of Pharmacy, Dankook University)
Lee Hyo Chun (College of Pharmacy, Dankook University)
Choi Yong Seok (College of Pharmacy, Dankook University)
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Nitarsone is an organoarsenic antiprotozoal drug widely used to treat blackhead disease in turkeys and chickens. However, since its biological conversion into inorganic arsenic, a carcinogen was known, its residue in foods should be regu-lated. Thus, here, a novel method to determine residual nitarsone in various food commodities (pork, milk, egg, halibut, eel, and shrimp) using QuEChERS and LC-MRM was developed. The developed method was successfully validated through specificity, linearity (coefficient of determination, at least 0.991), recovery (R, 63.6 - 85.6%), precision (the relative standard deviation of R, 0.5 - 10.6%), and sensitivity (the lower limit of quantitation, 5 ppb) by following the Ministry of food and drug safety (MFDS) guidelines. The present method is the first mean to quantitate nitarsone using LC-MRM, and it was designed to be conveniently merged into a new method to quantitate multiple veterinary drugs for the positive list system (PLS). Therefore, the present method could contribute to fortify the food safety system in South Korea.

nitarsone, food, QuEChERS, MRM, PLS

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Mass Spectrometry Letters