ACOMS+ 및 학술지 리포지터리 설명회

  • 한국과학기술정보연구원(KISTI) 서울분원 대회의실(별관 3층)
  • 2024년 07월 03일(수) 13:30
 

  • P-ISSN2233-4203
  • E-ISSN2093-8950
  • ESCI, SCOPUS, KCI

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  • P-ISSN 2233-4203
  • E-ISSN 2093-8950

Charge-Directed Peptide Backbone Dissociations of o-TEMPO-Bz-C(O)- Peptides

Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2013, v.4 no.4, pp.71-74
https://doi.org/10.5478/MSL.2013.4.4.71
Aeran Jeon (Sogang University)
Ji Hye Lee (Sogang University)
Hyuk Su Kwon (Sogang University)
Hyung Soon Park (Diatech Korea Co. Ltd.)
Moon Bong Jin (Sogang University)
Han Bin Oh (Sogang University)
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Abstract

In the present study, we report that the charge-directed (assisted) peptide dissociation products, such as b- and y-type peptidebackbone fragments, were the major products in MS/MS and MS3 applications of some o-TEMPO-Bz-C(O)-peptide ions, whileradical-driven dissociation products, such as a/x and c/z-type fragments, were previously shown to be the major products in the freeradical initiated peptide sequencing mass spectrometry (FRIPS MS). Those o-TEMPO-Bz-C(O)-peptides share a common feature intheir sequences, that is, the peptides do not include an arginine residue that has the highest proton affinity among free amino acids. The appearance of b- and y-type fragments as major products in FRIPS MS can be understood in terms of the so-called “mobile-protonmodel”. When the proton is highly mobilized by the absence of arginine, the chare-directed peptide dissociation pathways appearto be more competitive than the radical-driven dissociation pathways, in our FRIPS experiments.

keywords
Charge-directed dissociations, Peptide, Free radical initiated peptide sequencing, Mobile proton model, Radical chemistry


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투고일Submission Date
2013-12-01
수정일Revised Date
2013-12-02
게재확정일Accepted Date
2013-12-02
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