ACOMS+ 및 학술지 리포지터리 설명회

  • 한국과학기술정보연구원(KISTI) 서울분원 대회의실(별관 3층)
  • 2024년 07월 03일(수) 13:30
 

  • P-ISSN2233-4203
  • E-ISSN2093-8950
  • ESCI, SCOPUS, KCI

논문 상세

Home > 논문 상세
  • P-ISSN 2233-4203
  • E-ISSN 2093-8950

General Fragmentations of Alkaloids in Electrospray Ionization Tandem Mass Spectrometry

Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2013, v.4 no.4, pp.79-82
https://doi.org/10.5478/MSL.2013.4.4.79
Hee Jung Shim (Kyung Hee University)
Ji Ye Lee (Kyung Hee University)
Byungjoo Kim (Korea Research Institute of Standard and Science)
Jongki Hong (Kyung Hee University)
  • 다운로드 수
  • 조회수

Abstract

Various types of alkaloids observed in several herbal medicines were analyzed by electrospray ionization tandemmass spectrometry in positive ion mode. In the present study, MS/MS spectralpatterns were investigated for eight-types of alkaloids(aporpine, protoberberine, tetrahydroprotoberberine, benzylisoquinoline, protopine, phthalide, morpine, and bisbenzylisoquinoline). For aporpine- and protoberberine-type alkaloids, main fragmentations occurred at substituted groups on rigid ringstructures, not showing ring fusion. Interesting fragmentations due to iminolization and retro-Diels-Alder (RDA) reaction wereobserved in MS/MS spectra of protopine- and tetrahydroprotobereberine-type alkaloids. Also, several types of fragmentationssuch as inductive cleavage and α-cleavage, or bond cleavage between two ring structures were observed depending on theirstructural characteristics. These fragmentation patterns are expected to allow instant classification of the specific alkaloid type invarious MS/MS spectra of alkaloids.

keywords
Alkaloids, General fragmentation, MS/MS spectral patterns, Tandem mass spectrometry


참고문헌

1

Leung, W. C. (2003). . Prog. Neuropsychopharmacol. Biol. Psychiatry, 27, 775-.

2

Yokozawa, T.. (2004). . J. Pharm. Pharmacol, 56, 547-.

3

Kubo, M. (1994). . Biol. Pharm. Bull, 17, 262-.

4

Mesia, K. (2008). . Talanta, 76, 462-.

5

Zhou, Y. (2006). . Rapid Commum. Mass Spectrom, 20, 1030-.

6

Li, Y. (2004). . Anal. Chim. Acta, 508, 17-.

7

Chan, A. Y. W. (1999). . Clin. Chem, 45, 229-.

8

Iwasa, K. (2005). . J. Nat. Prod, 68, 992-.

9

Ma, C.-H. (2009). . Helv. Chim. Acta, 92, 379-.

10

Zhang, X. (2009). . Rapid Commum. Mass Spectrom, 23, 2903-.

11

Wang, D. (2004). . J. Mass Spectrom, 39, 1356-.

12

Wu, W. (2005). . J. Pharm. Biomed. Anal, 37, 437-.

13

Kim, K. H. (2010). . Bioorg. Med. Chem. Lett, 20, 4487-.

14

Schmidt, J. (2007). . Phytochemistry, 68, 189-.

15

Ding, B. (2007). . J. Pharm. Biomed. Anal, 45, 219-.

16

Jeong, E. -K. (2012). . Rapid Commun. Mass Spectrom, 26, 1661-.

17

Raith, K. (2005). . Eur. J. Mass Spectrom, 11, 325-.

18

Wu, W. N. (2004). . J. Pharm. Biomed. Anal, 34, 53-.

19

Sim, H. J. (2013). . Molecules, 18, 5235-.

투고일Submission Date
2013-12-09
수정일Revised Date
2013-12-17
게재확정일Accepted Date
2013-12-17
상단으로 이동

Mass Spectrometry Letters