Development of an Isotope Dilution Mass Spectrometry (IDMS)-Based Method for the Analysis of Ibuprofen

Lee Joonhee; Kim Byungjoo

doi:10.5478/MSL.2017.8.3.49

P-ISSN2233-4203
E-ISSN2093-8950
ESCI, SCOPUS, KCI

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P-ISSN 2233-4203
E-ISSN 2093-8950

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Vol.8, No.3

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Development of an Isotope Dilution Mass Spectrometry (IDMS)-Based Method for the Analysis of Ibuprofen

Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950

2017, v.8 no.3, pp.49-52

https://doi.org/10.5478/MSL.2017.8.3.49

Lee Joonhee (Korea Research Institute of Standard and Science)
Kim Byungjoo (Korea Research Institute of Standard and Science)

Lee, J., & Kim, B. (2017). Development of an Isotope Dilution Mass Spectrometry (IDMS)-Based Method for the Analysis of Ibuprofen. Mass Spectrometry Letters, 8(3), 49-52, https://doi.org/10.5478/MSL.2017.8.3.49

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Abstract

Ibuprofen is one of the most popular analgesic and antipyretic drugs. An isotope dilution mass spectrometry method based on LC/MS was developed as a candidate reference method for the accurate determination of ibuprofen in pharmaceutical tablets. Isotope labelled ibuprofen, ibuprofen-d 3 , was added as an internal standard into sample extracts. Ibuprofen and ibupro-fen-d 3 , was analysed by LC/MS in a selected ion monitoring (SIM) mode to detect ions at m/z 205 and 208, respectively. The repeatability and reproducibility of the developed ID-LC/MS method were tested for the validation and assessment of metrolog-ical quality of the method.

keywords: Ibuprofen, ID-LC/MS, Method Validation, Pharmaceuticals

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