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- P-ISSN 2233-4203
- E-ISSN 2093-8950
Ibuprofen is one of the most popular analgesic and antipyretic drugs. An isotope dilution mass spectrometry method based on LC/MS was developed as a candidate reference method for the accurate determination of ibuprofen in pharmaceutical tablets. Isotope labelled ibuprofen, ibuprofen-d 3 , was added as an internal standard into sample extracts. Ibuprofen and ibupro-fen-d 3 , was analysed by LC/MS in a selected ion monitoring (SIM) mode to detect ions at m/z 205 and 208, respectively. The repeatability and reproducibility of the developed ID-LC/MS method were tested for the validation and assessment of metrolog-ical quality of the method.
Huidobro, A. L. (2006). . J. Chromatogr. A, 1119, 238-.
Gasco-Lopez, A. I. (1999). . Pharm. Biomed. Anal, 21, 143-.
Sun, Y. (2003). . J. Pharm. Biomed. Anal, 30, 1611-.
Whelan, M. R. (2002). . J. Pharm. Biomed. Anal, 30, 1355-.
Tsikas, D. (2017). . J. Chromatogr. B, 1043, 158-.
Stubberud, K. P. (1998). . J. Chromatogr. A, 826, 92-.
Hamoudová, R. (2006). . J. Pharm. Biomed. Anal, 41, 1463-.
Palabiyik, İ. M. (2004). . J. Pharm. Biomed. Anal, 34, 473-.
Alnouti, Y. (2005). . J. Chromatogr. A, 1080, 99-.
Wu, J. (2010). . J. Chromatogr. A, 1217, 1471-.
Quinn, T. (1997). . J. Metrologia, 34, 61-.
Lee, J. (2013). . Anal. Chim. Acta, 787, 132-.
Shin, H. (2013). . Food Chem, 138, 1109-.
Lee, J. (2016). . J. Food Compos. Anal, 50, 49-.
Hyunju Shin. (2010). Development of an Isotope-Dilution Liquid Chromatography/Mass Spectrometric Method for the Accurate Determination of Acetaminophen in Tablets. Bulletin of the Korean Chemical Society, 31(12), 3663-3667.