- P-ISSN2799-2977
- E-ISSN2799-4066
6권 2호
초록
Abstract
Objectives: This study was aimed to evaluate the hemodynamic feasibility using pulse parameters as a way to establish safe dose guidelines for ChungSimWon, and to provide a foundation for developing evidence-based guidelines for clinical use. Methods: Thirty nine volunteers were recruited to participate in a study examining the changes in pulse wave characteristics following the ingestion of ChungSimWon, over a period of 2 weeks, and pulse wave measurements were taken before and after the administration. Pulse wave parameters were measured in this study using a 3-dimensional radial pulse tonometry device(DMP-Lifeplus). In addition, questionnaire, blood pressure, temperature, and body composition were also measured as secondary measures. Results: Fifteen minutes after administration of ChungSimWon, the non-adverse event group(non-AE) exhibited a statistically significant increase in several power and pressure-related parameters and heart pumping performance, including h1, h3, h4, h5, SA(Systolic Area), PA(Pulse Area), PW(Pulse Width), SV(Stroke Volume), SVI(Stroke Volume Index), CO(Cardiac Output) and decrease in SVRI(Systemic Vascular Resistance Index), while the adverse event group(AE) showed a trend of increasing SV, SVI, CO, applied pressure and decreasing Systemic Vascular Resistance Index(SVRI). After 2 weeks of administration, non-adverse event group(non-AE) exhibited significant changes in HRV(Heart Rate Variability) LHratio(Low frequency-High frequency ratio), applied pressure and hemodynamic parameters while adverse event group(AE) showed significant changes in SV and SVRI. Notably, there are significant differences between AE group and non-AE group in wfb(front back of w) ratio, STD(standard deviation) pulse rate and hemodynamic parameter before medication. Conclusion: These findings suggest that pulse parameters may be a useful way to establish safe dosing guidelines for ChungSimWon. Further research is needed to confirm these results and to develop evidence-based guidelines for clinical use
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Abstract
Objectives: We aimed to confirm the effect of Plantago depressa Willd (PD) pharmacopuncture, specifically a rich extract of polysaccharides and flavonoids, on reducing fat deposition in local areas using a mouse model of diet-induced obesity. Methods: Obesity was induced in C57BL/6 with a high-fat diet for 7 weeks. The right inguinal fat pad was injected with 100 μL of physiological saline as a control, and the left inguinal fat pad was injected with 100 μL of PD extract at a concentration of 0.6 mg (equivalent to 20 mg/kg). PD extract was injected a total of 6 times, 3 times a week for 2 weeks starting from the 5th week of high-fat diet feeding. After treatment, the weight of the inguinal fat pad were confirmed, and the size of adipocytes was assessed through histological analysis using H&E staining. Furthermore, Western blot analysis was conducted on enzymes associated with lipolysis to evaluate molecular changes both in vivo and in vitro. Results: In the inguinal fat treated with PD pharmacopuncture, a significant reduction in the weight and size of the inguinal adipose tissues was observed compared to the vehicle. The expression of hormone-sensitive lipase (HSL) and adipose triglyceride lipase (ATGL), factors related to lipolysis, was increased in the adipose tissue in the local area where PD was injected. Additionally, the formation of lipid droplets was suppressed, and enzymes related to lipolysis were increased by PD extract treatment in differentiated 3T3-L1 adipocytes. Conclusion: The PD pharmacopuncture effectively reduced fat mass in the inguinal fat pads of mice with obesity and promoted lipolysis by increasing the activity of lipolytic enzymes.
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Abstract
initiation of systemic inflammatory response. This study aimed to optimize the intestinal inflammation mouse model by injecting different doses of LPS. Methods: The experimental mice were induced by the intraperitoneal administration of 5, 10 and 20 mg/kg of LPS. After 12 hours, disease activity index (DAI) was evaluated by 2 different researchers with blinded test. Then, serum and colon tissues were obtained after sacrifice. Hematoxylin and eosin staining was performed to analyze the damage of intestinal tissues. Serum monocyte chemoattractant protein-1 (MCP-1) was estimated by enzyme-linked immunosorbent assay. Results: Injection with the 5, 10 and 20 mg/kg of LPS resulted in the increases of DAI score with the changes of fetal status such as diarrhea and hematochezia. However, there was no dose-dependent changes according to the doses of LPS. In addition, the colon length was not changed depends on the doses of LPS. The histopathological grades including intestinal barrier disruption, inflammatory cell infiltration and shape of villi were significantly increased by LPS injection. Moreover, serum MCP-1 levels were markedly increased with the concentrations of LPS. Conclusion: Taken together, LPS effectively induced the intestinal inflammation accompanied with the increment of serum chemokine and destruction of barrier.
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Abstract
Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder that remains one of the most significant medical challenges of the 21st century, characterized by relentless cognitive decline, memory impairment, and functional loss. Despite decades of research, effective disease-modifying therapies remain elusive, leaving an urgent need for novel therapeutic strategies. Heparan sulfate (HS), a highly heterogeneous glycosaminoglycan found ubiquitously in the extracellular matrix and on cell surfaces, has emerged as a crucial player in the complex pathophysiology of AD. Its interactions with amyloid-beta (Aβ) peptides promote aggregation and plaque formation, while its binding to hyperphosphorylated tau facilitates neurofibrillary tangle formation, both of which are hallmark features of AD. Additionally, HS modulates neuroinflammatory cascades by influencing microglial activation and cytokine release, further contributing to neuronal damage and disease progression. Beyond its pathogenic roles, HS represents a promising therapeutic target, with potential strategies ranging from synthetic HS mimetics to enzyme inhibitors designed to modulate its activity. In parallel, the integration of Korean Medicines (KM), which has shown efficacy in addressing neuroinflammatory and cognitive disorders through herbal and holistic approaches, offers a unique perspective in the quest for innovative AD treatments. Herbs such as Gastrodia elata and Poria cocos exhibit neuroprotective and anti-inflammatory properties, making them potential candidates for HS-modulating therapies. This review provides a detailed exploration of the biological significance of HS in AD, evaluates emerging therapeutic approaches, and highlights the potential synergy between modern biomedical advancements and the principles of KM. By bridging the gap between traditional knowledge and cutting-edge science, this synthesis lays the groundwork for a transformative, integrative paradigm in AD treatment, aiming to address both the pathological and symptomatic aspects of the disease.
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Abstract
Objectives: This study aimed to evaluate the clinical efficacy of local lipolysis pharmacopuncture LIPOSA through a retrospective chart review of patients seeking obesity treatment at Korean medical institutions. Methods: A retrospective multi-center study was conducted by analyzing medical records of patients who visited six Korean medical institutions for obesity treatment between January 2023 and April 2024. A total of 117 patients were included: 62 patients in the LIPOSA group (herbal medicine treatment with LIPOSA pharmacopuncture) and 55 patients in the control group (herbal medicine treatment only). Changes in body composition including weight, body mass index (BMI), skeletal muscle mass, body fat mass, and body fat percentage were analyzed. Results: Both groups showed improvements in obesity-related clinical indicators after treatment. The LIPOSA group demonstrated significantly greater reductions in body fat mass (-4.20 ± 4.08 kg vs -2.64 ± 1.96 kg, p = 0.0088) and body fat percentage (-3.20 ± 3.24% vs -1.88 ± 1.86%, p = 0.079) compared to the control group. Additionally, the LIPOSA group showed better preservation of skeletal muscle mass during treatment. Conclusion: The study demonstrates that LIPOSA pharmacopuncture combined with herbal medicine treatment is more effective in reducing body fat while preserving muscle mass compared to herbal medicine treatment alone, suggesting its potential as an effective treatment for localized obesity.
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Abstract
Objectives: The purpose of this study was to investigate the effective smoking cessation treatment in terms of Korean Medicine. Methods: Domestic and international articles regarding on the oriental medicine for smoking cessation were investigated through Pubmed, Korean studies Information Service System (KISS) and Google Scholar database. The keywords included ‘smoking’, ‘smoking cessation’, ‘oriental medicine’, ‘herbs’ and ‘therapy’. Firstly, each keyword were searched by combining each keyword approximately. Results: The current therapy for smoking cessation was described to compare with the alternative and complementary remedy. As result for searching keywords, the total number of papers searched was 83471 and final papers inspected was 61 after exclusion. We introduced various oriental medicine therapeutics including 3 herb formulation, 4 herbs and acupuncture based on the previous studies. Alternative and complementary remedy of oriental medicine for smoking cessation focused on the efficacy on the antioxidative activities, nicotine degradation activities and decrease of craving for tobacco. Conclusion: Because exposure of cigarette smoke induces severe health problems, effective smoking cessation would be necessary for smokers. Alternative and complementary therapies including herbs and acupuncture could be helpful to quit smoking over a long period of time without side effects.