- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Effects of Galhwahyejungtang (GHT) on Protection for？Alcohol-induced Liver Injury
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2005, v.26 no.1, pp.76-84
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(2005). Effects of Galhwahyejungtang (GHT) on Protection for？Alcohol-induced Liver Injury. Journal of Korean Medicine, 26(1), 76-84.
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Abstract
Objective: The purpose of this study was to examine the protective efficacy of GHT for alcoholic liver injury.Methods We measured the rate of alcohol oxidation, serum level of liver enzyme, lipid peroxidation level in liver tissue, and inflammatory related cytokine expressions in liver.Results GHT showed the liver protective effects, lowered the levels of AST, LDH, in serum and inhibited lipid peroxidation in liver tissue respectively, and enhanced alcohol oxidation. GHT treatment up-regulated IL-10 in liver, whereas down-regulated TNF-α, TGF-β and Fas ligand.Conclusion From these results, GHT is supposed to work in the liver protective roles not through pathway of alcohol metabolism but mainly by anti-inflammation activity in our model.
- keywords
- TNF-α, TGF-β, IL-10, alcohol, Galhwahyejungtang (GHT), TNF-α, TGF-β, IL-10, alcohol, Galhwahyejungtang (GHT)
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