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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

Effects of Galhwahyejungtang (GHT) on Protection for?Alcohol-induced Liver Injury

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2005, v.26 no.1, pp.76-84
안태규 (원광대학교)
신장우 (원광대학교)
조정효 (원광대학교)
유화승 (원광대학교)
이연열 (원광대학교)
이남현 (원광대학교)
윤담희 (원광대학교)
손찬규 (원광대학교)
조총관 (원광대학교)
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Abstract

Objective: The purpose of this study was to examine the protective efficacy of GHT for alcoholic liver injury.Methods We measured the rate of alcohol oxidation, serum level of liver enzyme, lipid peroxidation level in liver tissue, and inflammatory related cytokine expressions in liver.Results GHT showed the liver protective effects, lowered the levels of AST, LDH, in serum and inhibited lipid peroxidation in liver tissue respectively, and enhanced alcohol oxidation. GHT treatment up-regulated IL-10 in liver, whereas down-regulated TNF-α, TGF-β and Fas ligand.Conclusion From these results, GHT is supposed to work in the liver protective roles not through pathway of alcohol metabolism but mainly by anti-inflammation activity in our model.

keywords
TNF-α, TGF-β, IL-10, alcohol, Galhwahyejungtang (GHT), TNF-α, TGF-β, IL-10, alcohol, Galhwahyejungtang (GHT)


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