- P-ISSN 1010-0695
- E-ISSN 2288-3339
- Apply for Authority
- P-ISSN1010-0695
- E-ISSN2288-3339
Article Detail
Home > Article Detail
The Inhibitory Effects of Bimanbang-1 on theObese-mouse Fed High-fat Diet
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2008, v.29 no.2, pp.116-132
&
(2008). The Inhibitory Effects of Bimanbang-1 on theObese-mouse Fed High-fat Diet. Journal of Korean Medicine, 29(2), 116-132.
- Downloaded
- Viewed
Abstract
Objective: This study investigated the effects of Bimanbang-1 (肥滿1號方: here in after referred to BMB-1) on the obese gene and obese inhibitory. Methods: C57BL/6 mice were induced by high fat diet. Mice were divided into three groups (normal, high fat diet with control, high fat diet with BMB-1 extract) and fed for 15 weeks. Items of this experimental study are as follows: body weight change, final body weight, the weight change of the adipocytes in body, the level change of LFT, NEFA and creatinine, the expression of β3AR and leptin gene in primary adipocytes, the production change of leptin in primary adipocytes, the expression of β3AR, leptin and TNF-α in adipocytes tissue. Result: 1. All experimental groups showedthat the weight change decreased considerably and the high density group showedthat the final weight decreased considerably. 2. The high density group showed that the amount of the adipocyte in weight decreased considerably. 3. All experimental groups showedthat the amount of ALT decreased considerably, and AST decreased in the high density group. However, the amount of creatinine and glucose did not increase considerably. 4. All experimental groups showed that the amount of total cholesterol, LDL-cholesterol, triglyceride, and NEFA decreased, and HDL-cholesterol increased considerably. 5. The high density groups showedthat the amount of leptin decreased considerably. 6. All experimental groups showed that the revelation of β3AR in primary adipose cell and 3T3-L1 cell increased considerably, and that the revelation of leptin and TNF-α in primary adipose cellsand 3T3-L1 cells decreased considerably. 7. All experimental groups showed that the size of adipocyte in adipocytes tissue decreased. 8. All experimental groups showed that the adipose vacuoles in liver tissue decreased considerably. Conclusion: The findings suggest that Bimanbang-1 causes weight loss and histological change, thus it may be effective to treat obesity.
- keywords
- BMB-1 (Bimanbang-1), obese-mouse, obese gene, obese inhibitory, adipocyte, liver tissue.
Reference
1
1. 의학교육연수원. 가정의학. 서울:서울대학교출판부. 2003:1011.
2
2. 한방재활의학과학회. 한방재활의학과학. 서울:군자출판사. 2005:384-96.
3
3. 진광선. 비만의 연구 동향에 대한 분석. 대전대학교대학원. 2004.
4
4. Hewwit JK. The Genesis of Obesity ; What have genetic and environmental factors in relative body weight and human adiposity. Behav Genet. 1997;27(4):325-51.
5
5. 강재헌, 김남순. 한국의 비만 추이. 대한비만학회지. 2002;11(4):331-6.
6
6. 보건복지부. 2005 국민건강영양조사. 서울:보건복지부. 2006:38-44.
7
7. 대한가정의학과 비만연구회 편역. 비만치료의 최신지견. 서울:한미의학. 2005:21-31,35-7,291-2.
8
8. 탁양주, 이영성, 이진석, 강재헌. 최근 국내 비만 연구의 경향 (1984년부터 2002년까지). 대한비만학회지. 2004;13(1):1-13.
9
9. Hubert HB, Feinleib M, McNamara PM, Castelli WP. Obesity as an independent risk factor for cardiovascular disease:26-year follow up of participants in the Framingham Heart Study. Circulation. 1983;97:968-77.
10
10. Van Itallie TB. Health implications of overweight and obesity in the United States. Ann Intern Med. 1985;103(2):983-8.
11
11. 이가영, 박태진. 40세 이상의 일부 성인에서 비만이 건강에 미치는 영향. 가정의학회지. 1997; 18(3):284-294.(353)
12
12. 대한민국의학정보센터. KIMS OnLine. [cited 2006 Oct. 29];[3 screens]. Available from:URL: http://www.kimsonline.co.kr
13
13. 홍원식, 정교. 황제내경. 서울:동양의학연구원출판부. 1991:61,94,219-20,275.
14
14. 朱震亨. 丹溪心法附餘 上卷. 서울:大星文化社.. 1982:62,66-7,70,121,156,889.
15
15. 張介賓. 景岳全書. 上海:上海古籍出版社. 1991: 181-2,211-2.
16
16. 李東垣 外. 東垣醫書 十種 脾胃論. 서울:大成文化社. 1983:70-1.
17
17. 劉河間. 劉河間三六書. 서울:성보사. 1976:282.
18
18. 전국한의과대학 본초학교수 공저. 본초학. 서울:영림사. 1999:124-5,129,148,291-2,302,306, 347,354,365,409,427,445,448,460,466,493,496,510,536,523,540.
19
19. 이삼열 外. 臨床病理檢査法. 서울:연세대학교출판사. 2000:.230,238,262.
20
20. 최웅환. Uncoulpling protein. 大韓內分泌學會誌. 2000;15(4):453-60.
21
21. 대한임상의학연구소. 임상병리검사편람. 서울:의학문화사. 1992:158,162,173,223,224,231,246.
22
22. Behme MT. Leptin: Product of the obese gene. Nutr Today. 1996;31:138-141.
23
23. 대한비만학회. 임상비만학. 서울:고려의학. 2001: 26,40,89,95,204-5,219,407-14.
24
24. 해리슨내과학 편찬위원회 편. 내과학. 서울:정담. 1997:92-5,278-81.
25
25. 채영희. 綜合健康診斷 受診者의 肥滿持續에 따른 檢査所見에 관한 考察. 인제대학교보건대학원. 1993.
26
26. 金井泉, 金正光 편저. 임상검사법개요. 서울:고문사. 1989:429-45.
27
27. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR et al. Serum immunoreactive leptin concentration in normal weight and obese humans. N Engl J Med. 1996;334:292-295.
28
28. Fredrich RC, Hamann A, Anderson S, Lollmann B, Flier JS. Leptin levels reflect body lipid content in mice, Evidence for diet- induced resistance to leptin action. Nature Med. 1995;1(12):1311-4.(354)
29
29. Masuzaki H, Ogawa Y, Hosoda K, Kawada T, Fushiki T, Nakao K. Augmented expression of the obese gene in the adipose tissue from rats fed high-fat diet. Biochem Biophys. 1999; 140:35-42.
- Downloaded
- Viewed
- 0KCI Citations
- 0WOS Citations
Other articles from this issue
- Seasonal Variation of Acute Stroke- Hospital Based Study -
- Effects of Kamijihwang-tang on Immune Cells andCytokines in OVA-induced Asthmatic Mice
- Protective effects of Singi-pill on traumatic brain injury-induced apoptosis in rat hippocampal dentate gyrus
- Analgesic and anti-inflammatory effect of theaqueous extract of Angelica dahurica
- Survey Analysis of 101 Subjects UsingHerbalMedicine with Deer Antler
- The Effect of the Salvia miltiorrhiza on Axon RegenerationFollowing Central Nervous System Injury
- Comparative Study between the Finger PhotoplethysmographicWaveform of the Old and That of the Young Whose HarmonicsDeceased with Notch Filtration
- The Effects of Prunella vulgaris on the Cyto-pathological Alterations andExpression of Inflammatory Cytokines in Non-Bacterial Prostatitis Rat Model
- Effect of Whitmania pigra whitman on theAllergic Inflammatory Response
- A Survey on the Recognition of Pending Policy among OrientalDoctors Working in Oriental Medical Institutions
- Effects of Acupuncture on Autonomic Nervous System in NormalSubjects under Mental Stress
- The Inhibitory Effects of Bimanbang-1 on theObese-mouse Fed High-fat Diet
- Improved Axonal Regeneration Responses in the Injured SciaticNerve of Rats by Danggui Treatment
- A Study on the Inhibitory Effect of Yeongdamsagantang onAlzheimer in Aβ-oligomer-induced Neuro 2A Cell Lines
- Study of Instruments for Assessment and ClinicalResearch Trends in Common Cold
- Antimicrobial Effect on the Periodontal Pathogens andAnti-inflammatory Effect of Eriobotryae Folium
- more
Recommanded Articles
This website recommended the use the Chrome browser for journal website.