- P-ISSN 1010-0695
- E-ISSN 2288-3339
- Apply for Authority
- P-ISSN1010-0695
- E-ISSN2288-3339
Article Detail
Home > Article Detail
Antimicrobial Effect on the Periodontal Pathogens andAnti-inflammatory Effect of Eriobotryae Folium
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2008, v.29 no.2, pp.182-192
&
(2008). Antimicrobial Effect on the Periodontal Pathogens andAnti-inflammatory Effect of Eriobotryae Folium. Journal of Korean Medicine, 29(2), 182-192.
- Downloaded
- Viewed
Abstract
Objective: The purpose of this study was to evaluate on the antimicrobial effect on the periodontal pathogens and anti-inflammatory effect of Eriobotryae folium. Eriobotryae folium are constituent herbs of Gagamgamroum, which has been used for a long time in oriental medicine as a herbal medicine for treating halitosis and toothache. Method: Eriobotryae folium was prepared by extracting medicinal herb with water. We investigated antimicrobial activity by the minimum inhibitory concentration (MIC) test. We also investigated inhibition of IL-1β-induced collagenase (mmp-1), stromelysin-1 (mmp-3), interleukin-6 gene expression in human gingival fibroblasts using RT- PCR analysis. Result: The antimicrobial effects of Eriobotryae folium was evaluated with MIC against periodontopathogens; Porphyromonas gingivalis 2561, W50, A7A1-28, 9-14K-1, Prevotella intermedia 28, and Actinobacillus actinomycetemcomitans Y4. MICs of Eriobotryae folium were 1.25㎎/㎖, 2.5㎎/㎖, 0.625㎎/㎖, 1.25㎎/㎖, 10㎎/㎖ and 10㎎/㎖. The anti-inflammatory effect of Eriobotryae folium was evaluated with influence of herbs on the IL-1β-induced expression of mmp-1, mmp-3, and interleukin-6. IL-1β increased mmp-1, mmp-3, and interleukin-6 mRNA levels. Eriobotryae folium significantly inhibited IL-1β-induced mmp-1, mmp-3, and interleukin-6 gene expressions in a dose-dependent manner. Conclusion: These results suggested that Eriobotryae folium might reduce the excessive proteolytic capacity of the gingival fibroblast during inflammation and could be developed as a new drug for periodontitis.
- keywords
- Periodontitis, Eriobotryae folium, collagenase (mmp-1), stromelysin-1 (mmp-3), interleukin-6
Reference
1
1. 國家中醫葯管理局 中華本草 編委會. 中華本草. 上海. 上海科學技術出版社. 1998.
2
2. 전국한의과대학 본초학공동교재 편찬위원회. 본초학. 서울. 영림사. 2007.
3
3. 김영권, 한만덕. 구강미생물학. 서울. 고문사. 2003. pp.256. 321-366.
4
4. Lopez NJ. Occurrence of Actinobacillus Actinomycetemcomitans, Porphyromonas gin- givalis and Prevotella intermedia in progre- ssive adult periodontitis. Periodontol. 2000; 71(6): 948-954.
5
5. 장범석, 손성희, 정종평, 배기환. Magnolol과 Honokiol이 항균, 교원질분해효소, 세포독성 및 Cytokine생산에 미치는 영향. 대한치주과학회지. 1993; 23(1): 145-158.
6
6. 김태일, 최은정, 정종평, 한수부, 구영. 옥수수 불검화 추출물(Zea Mays L.)과 후박(Magnoliae cortex) 추출물 혼합물의 치주질환원인균에 대한 항균작용 및 치은섬유아세포 활성도에 미치는 영향. 대한치주과학회지. 2002; 32(1): 249-255.
7
7. 정종평,구영,배기환. 후박 및 은행엽 추출물의 항균, 항염 및 세포활성도에 미치는 영향. 대한치주과학회지.1995; 25(3): 478-486.
8
8. 김신규, 송주희, 김종배, 장기완, 전재규. 호장근의 항세균효과 및 항부착효과. 대한구강보건학회지. 2005; 29(1): 80-90.
9
9. 정진광, 정진형, 임성빈, 김정근, 소은희. 백두옹 추출물의 치주조직 세포에 활성도 및 항염 효과에 대한 연구. 대한치주과학회지. 2001; 31(1): 149-164.
10
10. 홍지연, 김상년, 하원호, 장석윤, 장인권, 박지은, 정성원, 엄유정, 최성호, 김종관. 천연추출물 Curcuma xanthorriza oil 함유치약의 치태 및 치은염 억제효과. 대한치주과학회지. 2005; 35(4): 1053-1071.
11
11. 조민정, 홍석진, 최충호, 정성숙. 오배자, 파고지 추출물 함유치약이 치태형석 억제에 미치는 영향. 대한구강보건학회지. 2005; 29(2): 141-152.
12
12. 이상인. 본초학. 서울: 도서출판수서원 . 1981. pp.340-341, 513-514.
13
13. 육창수, 김성만, 정진모, 정명숙, 김정화, 김승배. 한약의 약리·성분·임상응용. 서울:계축문화사. 1992. p.885-886.
14
14. Yang-Ae Choi, Tae Hyong Rhew, Kun-Young Park, Hae-young Chung and Jae-Chung Hah. Effects of Ursolic Acid Isolated from Eriob- otrya japonica on c-myc and c-Ha-ras Onco- gene Expression at Sarcoma 180 Cell. J. Korean Soc. Food Nutr. 1992; 21(3): 314-318.
15
15. 박춘근, 방경환, 이승은등. 수종 한약재 추출물의 Staphyllococcus aureus에 대한 항균활성. 한약작지. 2001; 9(4): 251-258.
16
16. 윤철호, 정지천, 김철호. 비파엽의 항당뇨병약리활성과 IL-1β유발당뇨병 마우스의 췌장인산화효소에 미치는 효과에 관한 연구. 동국한의학연구소논문집. 1998; 7(1): 75-86.
17
17. 정성제, 이진희, 송효남, 성낙술, 이승은, 백남인. 약용 식물 추출물의 항산화 활성 검색. J Korean Soc. Appl. Biol. Chem. 2004; 47(1): 135-140.(413)
18
18. Birkedal-Hansen H. Role of matrix metall- oproteinase in human periodontal disease. J Periodontol. 1993; 64(5): 474-484.
19
19. Ingman T, Tervahartiala T, Ding Y, Tschesche H, Haerian A, Kinane DF, Konttinen YT, Sorsa T. Matrix metalloproteinases and their inhibitors in gingival crevicular fluid and saliva of periodontitis patients. Clin Periodontol. 1996; 23(12): 1127-1132.
20
20. 김세원. Interleukin-1ϐ와 Tumor necrosis factor-α가 치은섬유모세포와 치주인대세포의 matrix metalloproteinase 유리에 미치는 영향. 대한 구강내과학회지. 2003; 28(4): 455-464.
21
21. Cox SW, Eley BM, Kiili M, Asikainen, Tervahartiala T, Sorsa T. Collagen degradation by interleukin-1beta -stimulated gingival fibroblasts is accompanied by release and activation of multiple matrix metalloproteinase and cysteine proteinases. Oral Dis. 2006; 12 (1): 34-40.
22
22. Paschalina Goutoudi, Evdoxia Diza, Malam- atenia Arvanitidou. Effect of periodontal therapy on crevicular fluid interleukin-1 and interleukin-10 levels in chronic periodontitis. J Dent. 2004; 32: 511-520.
23
23. 이상인. 본초학. 서울: 도서출판수서원 . 1981. pp.340-341, 513-514.
24
24. 吳謙등. 醫宗金鑑. 서울: 대성문화사. 1983. p.201-203.
25
25. 전국치주과학교수협의회. 치주과학. 서울: 군자출판사. 2004. p.116.
26
26. 장현선, 박문규, 국중기, 김화숙, 김병옥. Cefixime의 치주 병원성 세균 6종에 대한 항균효과. 대한치주과학회지. 2005; 35(2): 401-411.
27
27. Makela M, Salo T, Uitto VJ, Larjava H. Matrix metalloprotainase(MMP-2 and MMP-9) of the oral cavity ; cellular origin and relationship to periodontal status. J Dent Res. 1994; 73: 1397 -1406.(414)
28
28. Tataka DN. Interleukin-1 bone metabolism, a review. J Periodontal. 1993; 64: 416-431.
29
29. Makela M, Salo T, Uitto VJ, Larjava H. Matrix metalloprotainase(MMP-2 and MMP-9) of the oral cavity ; cellular origin and relationship to periodontal status. J Dent Res. 1994; 73: 1397- 1406.
30
30. Gregory I, Goldberg, Scott M, Wilhelm, Annemarie Kronberger, Eugene A, Bauer, Gregory A, Grant, and Arthur Z. Eisen. Human Fibroblast Collagenase. Complete primary structure and homology to an oncology trans- formation-induced rat protein. J Biol Chem. 1986; 261(14): 6600-6605.
31
31. Beklen A, Tuter G, Sorsa T, Hanemaaijer R, Virtanen I, Tervahartiala T, Konttinen YT. Gingival tissue and crevicular fluid co-oper- ation in adult periodontitis. J Dent Res. 2006; 85(1) : 59-63.
32
32. Shih-Jung Lin, Yung-Li Chen, Mark Yen-Bin Kuo, Chuan-Li Li, Hsein-Kun Lu. Measurement of gp130 cytokines-Oncostatin M and IL-6 in gingival crevicular fluid of patients with chronic periodontitis. Cytokine. 2005; 30(4): 160-167.
- Downloaded
- Viewed
- 0KCI Citations
- 0WOS Citations
Other articles from this issue
- Seasonal Variation of Acute Stroke- Hospital Based Study -
- Effects of Kamijihwang-tang on Immune Cells andCytokines in OVA-induced Asthmatic Mice
- Protective effects of Singi-pill on traumatic brain injury-induced apoptosis in rat hippocampal dentate gyrus
- Analgesic and anti-inflammatory effect of theaqueous extract of Angelica dahurica
- Survey Analysis of 101 Subjects UsingHerbalMedicine with Deer Antler
- The Effect of the Salvia miltiorrhiza on Axon RegenerationFollowing Central Nervous System Injury
- Comparative Study between the Finger PhotoplethysmographicWaveform of the Old and That of the Young Whose HarmonicsDeceased with Notch Filtration
- The Effects of Prunella vulgaris on the Cyto-pathological Alterations andExpression of Inflammatory Cytokines in Non-Bacterial Prostatitis Rat Model
- Effect of Whitmania pigra whitman on theAllergic Inflammatory Response
- A Survey on the Recognition of Pending Policy among OrientalDoctors Working in Oriental Medical Institutions
- Effects of Acupuncture on Autonomic Nervous System in NormalSubjects under Mental Stress
- The Inhibitory Effects of Bimanbang-1 on theObese-mouse Fed High-fat Diet
- Improved Axonal Regeneration Responses in the Injured SciaticNerve of Rats by Danggui Treatment
- A Study on the Inhibitory Effect of Yeongdamsagantang onAlzheimer in Aβ-oligomer-induced Neuro 2A Cell Lines
- Study of Instruments for Assessment and ClinicalResearch Trends in Common Cold
- Antimicrobial Effect on the Periodontal Pathogens andAnti-inflammatory Effect of Eriobotryae Folium
- more
Recommanded Articles
This website recommended the use the Chrome browser for journal website.