- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Improved Axonal Regeneration Responses in the Injured SciaticNerve of Rats by Danggui Treatment
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2008, v.29 no.2, pp.133-150
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(2008). Improved Axonal Regeneration Responses in the Injured SciaticNerve of Rats by Danggui Treatment. Journal of Korean Medicine, 29(2), 133-150.
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Abstract
Objective: This study was performed to examine Danggui (DG, Angelica gigas Nakai)’s potential activity for promoting axonal regeneration in the injured peripheral nerve. Methods: Using the sciatic nerve in the rats, DG extract 5 ㎕(10 ㎎/㎖ in 0.5% saline) was dripped into the injury site of the nerve. Results: DG treatment facilitated axonal elongation responses in the distal portion to the injury site. GAP-43 protein levels were upregulated by DG treatment in the injured nerve and also in the DRG, suggesting the induction of GAP-43 expression at gene expression level after nerve injury. Phospho-Erk1/2 protein levels were upregulated in the injured nerve area and also in the DRG, suggesting retrograde transport of phospho-Erk1/2 protein from the injury area to the cell body. Cdc2 protein levels were slightly upregulated by DG treatment. DG treatment increased the number of non-neuronal cells in the distal portion to the injury site. Conclusions: The present data suggest that DG is effective for enhanced axonal regrowth after sciatic nerve injury.
- keywords
- Danggui (DG, Angelica gigas Nakai), sciatic nerve, axonal regeneration
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