- P-ISSN 1010-0695
- E-ISSN 2288-3339
- Log In/Sign Up
- P-ISSN1010-0695
- E-ISSN2288-3339
Article Detail
Home > Article Detail
The Effects of Prunella vulgaris on the Cyto-pathological Alterations andExpression of Inflammatory Cytokines in Non-Bacterial Prostatitis Rat Model
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2008, v.29 no.2, pp.71-80
(2008). The Effects of Prunella vulgaris on the Cyto-pathological Alterations andExpression of Inflammatory Cytokines in Non-Bacterial Prostatitis Rat Model. Journal of Korean Medicine, 29(2), 71-80.
- Downloaded
- Viewed
Abstract
Objective: There is increasing evidence that chronic non-bacterial prostatitis is recognized to be a local inflammatory disease, and there is substantiating evidence to support the role of the inflammatory responses in its pathogenesis, and clinical value in the evaluation of therapeutic efficacy. Prunella vulgaris has been traditionally used in treatment of inflammatory diseases, including of scrofula, goiter, and allergy diseases. In this study, we investigated the effects of Prunella vulgaris on inflammatory cytokines and cytopathological alternation in the rat model of non-bacterial prostatitis induced by castration and 17β-estradiol treatment. Methods: Two-month-old rats were treated with 17β-estradiol after castration for induction of experimental non-bacterial prostatitis, which is similar to human chronic prostatitis in histopathological profiles. Prunella vulgaris as an experimental specimen, and testosterone as a positive control, were administered orally. The prostates were evaluated by histopathological parameters including the epithelial score and epithelial-stromal ratio for glandular damage, and the expression of inflammatory cytokine genes including the interleukin (IL)-1β, IL-5, IL-12, and tumor necrosis factor (TNF)-α. Results: While prostates of control rats revealed severe acinar gland atrophy and stromal proliferation, the rats treated with Prunella vulgaris showed a diminished range of tissue damage. Epithelial score was improved in Prunella vulgaris over that of the control (P<0.05). The epithelial-stromal ratio was lower with Prunella vulgaris when compared to that of the control (P<0.05). In the reverse transcription-polymerase chain reaction (RT-PCR) of inflammatory cytokine genes, Prunella vulgaris inhibited the expression of IL-1β and TNF-α genes, while it modulated the expression of IL-5, which is an anti-inflammatory cytokine. Conclusions: These findings suggest that Prunella vulgaris may protect the glandular epithelial cells and also inhibit stromal proliferation in association with the immune modulation including the suppression of inflammatory cytokines and promotion of anti-inflammatory cytokine. From theses results, we suggest that Prunella vulgaris could be a useful remedy agent for treating chronic non-bacterial prostatitis.
- keywords
- chronic non-bacterial prostatitis, Prunella vulgaris, inflammatory cytokine, epithelial-stromal ratio, epithelial score.
Reference
1
1. 대한비뇨기과학회. 비뇨기과학, 서울: 고려의학; 1996, p.156-160.
2
2. 두호경. 東醫腎系學, 서울: 東洋醫學硏究院; 1993, p. 681-688.
3
3. Liang CZ, Zhang XJ, Hao ZY, Yang S, Wang DB, Shi HQ, Liu C. An epidemiological study of patients with chronic prostatitis. BJU Int. 2004;94:568-570.
4
4. Pontari MA, Ruggieri MR. Mechanisms in prostatitis/chronic pelvic pain syndrome. J Urol. 2004;172:839-845.
5
5. Fowler JE Jr. Prostatitis. In:Gillenwater JA, Howard SS, Duckett JW. Adult and Pediatric Urology. 2nd ed. St. Loise. Mosby-Year Book. 1991. p. 1395-1423.
6
6. Angwafo FF 3rd, Zaher A, Befidi-Mengue R, Wonkam A, Takougang I, Powell I, Murphy G. The National Health Survey Team for The National Epidemiology Board of Cameroon. High-grade intra-epithelial neoplasia and prostate cancer in Dibombari, Cameroon. Prostate Cancer Prostatic Dis. 2003;6:34-38.(302)
7
7. Steenkamp V, Gouws MC, Gulumian M, Elgorashi EE, van Staden J. Studies on antiba- cterial, anti-inflammatory and antioxidant activity of herbal remedies used in the treatment of benign prostatic hyperplasia and prostatitis. J Ethnopharmacol. 2006;103(1):71-75.
8
8. 이병철, 김상우, 안영민, 두호경, 안세영. 해금사가 만성 비세균성 전립선염 모델에서 혈액학적 및 세포조직학적 변화에 미치는 영향. 대한한방내과학회지. 2006;27(3):664-676.
9
9. 김순일, 안영민, 안세영, 두호경, 이병철. 황백이 만성 비세균성 전립선염 모델에서 혈액학적 및 세포조직학적 변화에 미치는 영향. 대한한의학회지. 2006;67(3):51-62.
10
10. 본초학교실. 본초학. 서울: 영림사; 1992, p. 169-170.
11
11. Kim SY, Kim SH, Shin HY, Lim JP, Chae BS, Park JS, Hong SG, Kim MS, Jo DG, Park WH, Shin TY. Effects of Prunella vulgaris on mast cell-mediated allergic reaction and infla- mmatory cytokine production.Exp Biol Med (Maywood). 2007;232(7):921-6.
12
12. Effects of androgen deprivation on chronic bacterial prostatitis in a rat model. Int J Urol. 2003;10:485-491.
13
13. Harris MT, Feldberg RS, Lau KM, Lazarus NH, Cochrane DE. Expression of proinflammatory genes during estrogen-induced inflammation of the rat prostate. Prostate. 2000;44(1):19-25.
14
14. Kamijo T, Sato S, Kitamura T. Effect of cernitin pollen-extract on experimental nonbacterial prostatitis in rats. Prostate. 2001;49:122-131.
15
15. Naslund MJ, Strandberg JD, Coffey DS. The role of androgens and estrogens in the pathog- enesis of experimental nonbacterial prostatitis. J Urol 1988;140:1049-1053.
16
16. Seethalakshmi L, Bala RS, Malhotra RK, Austin-ritchie T, Miller-Graziano C, Menon M, Luber-Narod J. 17β-Estradiol induced prostatitis in the rat is an autoimmune disease. J Urol 1996;156:1838-1842.
17
Lundgren R, Holmquist B, Hesselvik M, Muntzig J. Treatment of prostatitis in the rat. The Prostate 1984;5:277-284
18
Nikaido T, Ohmoto T, Kinoshita T, Sankawa U, Nishibe S, Hisada S. Inhibition of cyclic AMP phosphodiesterase by lignans. Chem. Pharm. Bull. 1981;29(12): 3586-3592.
19
18. Ponniah S, Arah I, Alexander RB. PSA is a candidate self-antigen in autoimmune chronic prostatitis/chronic pelvic pain syndrome. Prostate. 2000;44:49-54.
20
19. Scattoni V, Raber M, Montorsi F, Da Pozzo L, Brausi M, Calori G, Freschi M, Rigatti P. Percent of free serum prostate-specific antigen and histological findings in patients undergoing open prostatectomy for benign prostatic hyper- plasia. Eur Urol. 1999;36:621-630.
- Downloaded
- Viewed
- 0KCI Citations
- 0WOS Citations
Other articles from this issue
- Seasonal Variation of Acute Stroke- Hospital Based Study -
- Effects of Kamijihwang-tang on Immune Cells andCytokines in OVA-induced Asthmatic Mice
- Protective effects of Singi-pill on traumatic brain injury-induced apoptosis in rat hippocampal dentate gyrus
- Analgesic and anti-inflammatory effect of theaqueous extract of Angelica dahurica
- Survey Analysis of 101 Subjects UsingHerbalMedicine with Deer Antler
- The Effect of the Salvia miltiorrhiza on Axon RegenerationFollowing Central Nervous System Injury
- Comparative Study between the Finger PhotoplethysmographicWaveform of the Old and That of the Young Whose HarmonicsDeceased with Notch Filtration
- The Effects of Prunella vulgaris on the Cyto-pathological Alterations andExpression of Inflammatory Cytokines in Non-Bacterial Prostatitis Rat Model
- Effect of Whitmania pigra whitman on theAllergic Inflammatory Response
- A Survey on the Recognition of Pending Policy among OrientalDoctors Working in Oriental Medical Institutions
- Effects of Acupuncture on Autonomic Nervous System in NormalSubjects under Mental Stress
- The Inhibitory Effects of Bimanbang-1 on theObese-mouse Fed High-fat Diet
- Improved Axonal Regeneration Responses in the Injured SciaticNerve of Rats by Danggui Treatment
- A Study on the Inhibitory Effect of Yeongdamsagantang onAlzheimer in Aβ-oligomer-induced Neuro 2A Cell Lines
- Study of Instruments for Assessment and ClinicalResearch Trends in Common Cold
- Antimicrobial Effect on the Periodontal Pathogens andAnti-inflammatory Effect of Eriobotryae Folium
- more
Recommanded Articles
This website recommended the use the Chrome browser for journal website.